Selective C-N Bond-Forming Reaction of 2,6-Dibromopyridine with Amines

A practical and efficient protocol for the syntheses of 6-substituted 2-bromopyridine compounds has been developed by using a selective copper-catalyzed C-N bond-forming reaction between 2,6-dibromopyridine and a range of amines. The major advantage of this protocol is the complete control of selectivity of the pyridine bromine atom for the C-N cross-coupling reaction. There are few reported syntheses of unsymmetrical 2,6-disubstituted pyridine-bridged compounds because of their complicated preparations. Although this is the case, a new series of these unsymmetrical compounds have been successfully prepared in two steps by using this copper-catalyzed coupling approach.