Nuclear reprogramming and pluripotency

被引：345

作者：

Hochedlinger, Konrad

Jaenisch, Rudolf ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02142 USA

[2] Whitehead Inst, Cambridge, MA 02142 USA

[3] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE | 2006年 / 441卷 / 7097期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature04955

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.

引用

页码：1061 / 1067

页数：7

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