Nuclear reprogramming and pluripotency

被引：345
作者：
Hochedlinger, Konrad
Jaenisch, Rudolf [1 ]
机构：
[1] MIT, Dept Biol, Cambridge, MA 02142 USA
[2] Whitehead Inst, Cambridge, MA 02142 USA
[3] MIT, Dept Biol, Cambridge, MA 02142 USA
来源：
NATURE | 2006年 / 441卷 / 7097期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature04955
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.
引用
收藏
页码：1061 / 1067
页数：7
相关论文
共 100 条
[1]   From teratocarcinomas to embryonic stem cells [J].
Andrews, PW .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 357 (1420) :405-417
[2]   Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors [J].
Baba, Y ;
Garrett, KP ;
Kincade, PW .
IMMUNITY, 2005, 23 (06) :599-609
[3]   Epidermal growth factor receptor and Ink4a/Arf:: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis [J].
Bachoo, RM ;
Maher, EA ;
Ligon, KL ;
Sharpless, NE ;
Chan, SS ;
You, MJJ ;
Tang, Y ;
DeFrances, J ;
Stover, E ;
Weissleder, R ;
Rowitch, DH ;
Louis, DN ;
DePinho, RA .
CANCER CELL, 2002, 1 (03) :269-277
[4]   A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].
Bernstein, BE ;
Mikkelsen, TS ;
Xie, XH ;
Kamal, M ;
Huebert, DJ ;
Cuff, J ;
Fry, B ;
Meissner, A ;
Wernig, M ;
Plath, K ;
Jaenisch, R ;
Wagschal, A ;
Feil, R ;
Schreiber, SL ;
Lander, ES .
CELL, 2006, 125 (02) :315-326
[5]   Plasticity of cell fate: Insights from heterokaryons [J].
Blau, HM ;
Blakely, BT .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1999, 10 (03) :267-272
[6]  
Blelloch RH, 2004, P NATL ACAD SCI USA, V101, P13985, DOI 10.1073/pnas.0405015101
[7]   Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus [J].
Blelloch, Robert ;
Wang, Zhongde ;
Meissner, Alex ;
Pollard, Steven ;
Smith, Austin ;
Jaenisch, Rudolf .
STEM CELLS, 2006, 24 (09) :2007-2013
[8]   Oct4 distribution and level in mouse clones:: consequences for pluripotency [J].
Boiani, M ;
Eckardt, S ;
Schöler, HR ;
McLaughlin, KJ .
GENES & DEVELOPMENT, 2002, 16 (10) :1209-1219
[9]   Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei [J].
Bortvin, A ;
Eggan, K ;
Skaletsky, H ;
Akutsu, H ;
Berry, DL ;
Yanagimachi, R ;
Page, DC ;
Jaenisch, R .
DEVELOPMENT, 2003, 130 (08) :1673-1680
[10]   Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].
Boyer, LA ;
Plath, K ;
Zeitlinger, J ;
Brambrink, T ;
Medeiros, LA ;
Lee, TI ;
Levine, SS ;
Wernig, M ;
Tajonar, A ;
Ray, MK ;
Bell, GW ;
Otte, AP ;
Vidal, M ;
Gifford, DK ;
Young, RA ;
Jaenisch, R .
NATURE, 2006, 441 (7091) :349-353
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