SMART: a web-based tool for the study of genetically mobile domains

被引：1085
作者：
Schultz, J
Copley, RR
Doerks, T
Ponting, CP
Bork, P
机构：
[1] European Mol Biol Lab, D-69012 Heidelberg, Germany
[2] Max Delbruck Ctr Mol Med, Berlin, Germany
[3] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
来源：
NUCLEIC ACIDS RESEARCH | 2000年 / 28卷 / 01期
关键词：
D O I：
10.1093/nar/28.1.231
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de). More than 400 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system, User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.
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收藏
页码：231 / 234
页数：4
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