Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid

被引：10

作者：

Carta, Gianfranca ^{[1
]}

Murru, Elisabetta ^{[1
]}

Cordeddu, Lina ^{[2
]}

Ortiz, Berenice ^{[3
]}

Giordano, Elena ^{[4
]}

Belury, Martha A. ^{[5
]}

Quadro, Loredana ^{[6
,7
]}

Banni, Sebastiano ^{[1
]}

机构：

[1] Univ Cagliari, Dept Biomed Sci, I-09042 Cagliari, Italy

[2] Karolinska Inst, Dept Biosci & Nutr, S-14183 Stockholm, Sweden

[3] Mem Sloan Kettering Canc Ctr, Gerstner Sloan Kettering Grad Sch Biomed Sci, New York, NY 10065 USA

[4] CEI UAM CSIC, Madrid Inst Adv Studies IMDEA Food, Lab Funct Foods, Madrid 28049, Spain

[5] Ohio State Univ, Dept Human Nutr, Columbus, OH 43210 USA

[6] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[7] Rutgers State Univ, Rutgers Ctr Lipid Res, New Brunswick, NJ 08901 USA

来源：

NUTRIENTS | 2014年 / 6卷 / 03期

关键词：

conjugated linoleic acid (CLA); retinol; vitamin A; retinol binding protein (RBP); oleoylethanolamide (OEA); palmitoylethanolamide (PEA); peroxisome proliferator-activated receptor-alpha (PPAR); PROLIFERATOR-ACTIVATED RECEPTORS; POLYUNSATURATED FATTY-ACIDS; RETINOL-BINDING-PROTEIN; GENE-EXPRESSION; PHYSIOLOGICAL-ROLE; NUCLEAR RECEPTORS; PPAR-ALPHA; LIVER; CYTOCHROME-P450; ACCUMULATION;

D O I：

10.3390/nu6031262

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR- and RXR heterodimer. We also present preliminary data that may position PPAR- at the crossroads between the metabolism of lipids and vitamin A.

引用

页码：1262 / 1272

页数：11

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