Concise Review: Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer: The Role of Cancer Stem Cells

被引：30
作者：
Del Re, Marzia [1 ]
Arrigoni, Elena [1 ]
Restante, Giuliana [1 ]
Passaro, Antonio [2 ]
Rofi, Eleonora [1 ]
Crucitta, Stefania [1 ]
De Marinis, Filippo [2 ]
Di Paolo, Antonello [1 ]
Danesi, Romano [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, Clin Pharmacol & Pharmacogenet Unit, Pisa, Italy
[2] European Inst Oncol, Div Thorac Oncol, Milan, Italy
来源：
STEM CELLS | 2018年 / 36卷 / 05期
关键词：
Cancer stem cells; Treatment resistance; Tyrosine kinase inhibitors; Biomarkers; Tumor heterogeneity; GROWTH-FACTOR-RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ACQUIRED-RESISTANCE; EGFR-TKI; DRUG-RESISTANCE; DNA METHYLATION; GENETIC-HETEROGENEITY; TUMOR HETEROGENEITY; T790M MUTATION; PROTEIN-KINASE;
D O I：
10.1002/stem.2787
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Among the potential mechanisms involved in resistance to tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer, the manifestation of stem-like properties in cancer cells seems to have a crucial role. Alterations involved in the development of TKI resistance may be acquired in a very early phase of tumorigenesis, supporting the hypothesis that these aberrations may be present in cancer stem cells (CSCs). In this regard, the characterization of tumor subclones in the initial phase and the identification of the CSCs may be helpful in planning a specific treatment to target selected biomarkers, suppress tumor growth, and prevent drug resistance. The aim of this review is to elucidate the role of CSCs in the development of resistance to TKIs and its implication for the management of patients.
引用
收藏
页码：633 / 640
页数：8
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