Post-Translational Modification of ZEB Family Members in Cancer Progression

被引:18
作者
Park, Mi Kyung [1 ,2 ]
Lee, Ho [1 ]
Lee, Chang Hoon [2 ]
机构
[1] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea
[2] Dongguk Univ, Coll Pharm, Seoul 04620, South Korea
关键词
zinc finger E-box binding homeobox (ZEB); post-translational modifications (PTM); cancer progression; EPITHELIAL-MESENCHYMAL TRANSITION; SMAD-INTERACTING PROTEIN-1; E-CADHERIN EXPRESSION; CELL CARCINOMA METASTASIS; PROMOTES TUMOR-METASTASIS; REGULATES E-CADHERIN; HOMEOBOX; ZEB1; NF-KAPPA-B; ZINC-FINGER; TGF-BETA;
D O I
10.3390/ijms232315127
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play essential roles in physiological and pathological processes. In addition, PTM functions in tumour development and progression. Zinc finger E-box binding homeobox (ZEB) family homeodomain transcription factors, such as ZEB1 and ZEB2, play a pivotal role in tumour progression and metastasis by induction epithelial-mesenchymal transition (EMT), with activation of stem cell traits, immune evasion and epigenetic reprogramming. However, the relationship between ZEB family members' post-translational modification (PTM) and tumourigenesis remains largely unknown. Therefore, we focussed on the PTM of ZEBs and potential therapeutic approaches in cancer progression. This review provides an overview of the diverse functions of ZEBs in cancer and the mechanisms and therapeutic implications that target ZEB family members' PTMs.
引用
收藏
页数:13
相关论文
共 127 条
  • [41] TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion
    Joseph, J. V.
    Conroy, S.
    Tomar, T.
    Eggens-Meijer, E.
    Bhat, K.
    Copray, S.
    Walenkamp, A. M. E.
    Boddeke, E.
    Balasubramanyian, V.
    Wagemakers, M.
    den Dunnen, W. F. A.
    Kruyt, F. A. E.
    [J]. CELL DEATH & DISEASE, 2014, 5 : e1443 - e1443
  • [42] Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
    Julien, S.
    Puig, I.
    Caretti, E.
    Bonaventure, J.
    Nelles, L.
    van Roy, F.
    Dargemont, C.
    Garcia de Herreros, A.
    Bellacosa, A.
    Larue, L.
    [J]. ONCOGENE, 2007, 26 (53) : 7445 - 7456
  • [43] The basics of epithelial-mesenchymal transition
    Kalluri, Raghu
    Weinberg, Robert A.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) : 1420 - 1428
  • [44] CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target
    Kalra, Rajkumar S.
    Chaudhary, Anupama
    Yoon, A-Rum
    Bhargava, Priyanshu
    Omar, Amr
    Garg, Sukant
    Yun, Chae-Ok
    Kaul, Sunil C.
    Wadhwa, Renu
    [J]. ONCOGENESIS, 2018, 7
  • [45] Retinoic acid regulates the ubiquitin-proteasome system in a middle cerebral artery occlusion animal model
    Kang, Ju-Bin
    Shah, Murad-Ali
    Park, Dong-Ju
    Koh, Phil-Ok
    [J]. LABORATORY ANIMAL RESEARCH, 2022, 38 (01)
  • [46] Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
    Kapuria, Vaibhav
    Peterson, Luke F.
    Fang, Dexing
    Bornmann, William G.
    Talpaz, Moshe
    Donato, Nicholas J.
    [J]. CANCER RESEARCH, 2010, 70 (22) : 9265 - 9276
  • [47] Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB
    Katoh, Masuko
    Katoh, Masaru
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (06) : 1737 - 1742
  • [48] Genomic correlates of response to immune checkpoint blockade
    Keenan, Tanya E.
    Burke, Kelly P.
    Van Allen, Eliezer M.
    [J]. NATURE MEDICINE, 2019, 25 (03) : 389 - 402
  • [49] The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
    Krebs, Angela M.
    Mitschke, Julia
    Losada, Maria Lasierra
    Schmalhofer, Otto
    Boerries, Melanie
    Busch, Hauke
    Boettcher, Martin
    Mougiakakos, Dimitrios
    Reichardt, Wilfried
    Bronsert, Peter
    Brunton, Valerie G.
    Pilarsky, Christian
    Winkler, Thomas H.
    Brabletz, Simone
    Stemmler, Marc P.
    Brabletz, Thomas
    [J]. NATURE CELL BIOLOGY, 2017, 19 (05) : 518 - +
  • [50] Postnatal Dynamics of Zeb2 Expression in Rat Brain: Analysis of Novel 3' UTR Sequence Reveals a miR-9 Interacting Site
    Kropivsek, Klara
    Pickford, Jasmine
    Carter, David A.
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 52 (01) : 138 - 147