Post-Translational Modification of ZEB Family Members in Cancer Progression

被引：18
作者：
Park, Mi Kyung [1 ,2 ]
Lee, Ho [1 ]
Lee, Chang Hoon [2 ]
机构：
[1] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea
[2] Dongguk Univ, Coll Pharm, Seoul 04620, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
关键词：
zinc finger E-box binding homeobox (ZEB); post-translational modifications (PTM); cancer progression; EPITHELIAL-MESENCHYMAL TRANSITION; SMAD-INTERACTING PROTEIN-1; E-CADHERIN EXPRESSION; CELL CARCINOMA METASTASIS; PROMOTES TUMOR-METASTASIS; REGULATES E-CADHERIN; HOMEOBOX; ZEB1; NF-KAPPA-B; ZINC-FINGER; TGF-BETA;
D O I：
10.3390/ijms232315127
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play essential roles in physiological and pathological processes. In addition, PTM functions in tumour development and progression. Zinc finger E-box binding homeobox (ZEB) family homeodomain transcription factors, such as ZEB1 and ZEB2, play a pivotal role in tumour progression and metastasis by induction epithelial-mesenchymal transition (EMT), with activation of stem cell traits, immune evasion and epigenetic reprogramming. However, the relationship between ZEB family members' post-translational modification (PTM) and tumourigenesis remains largely unknown. Therefore, we focussed on the PTM of ZEBs and potential therapeutic approaches in cancer progression. This review provides an overview of the diverse functions of ZEBs in cancer and the mechanisms and therapeutic implications that target ZEB family members' PTMs.
引用
收藏
页数：13
相关论文
共 127 条
  • [1] Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
    Aghdassi, Ali
    Sendler, Matthias
    Guenther, Annett
    Mayerle, Julia
    Behn, Claas-Olsen
    Heidecke, Claus-Dieter
    Friess, Helmut
    Buechler, Markus
    Evert, Matthias
    Lerch, Markus M.
    Weiss, Frank Ulrich
    [J]. GUT, 2012, 61 (03) : 439 - 448
  • [2] Formylglycine, a Post-Translationally Generated Residue with Unique Catalytic Capabilities and Biotechnology Applications
    Appel, Mason J.
    Bertozzi, Carolyn R.
    [J]. ACS CHEMICAL BIOLOGY, 2015, 10 (01) : 72 - 84
  • [3] Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression
    Bakiri, L.
    Macho-Maschler, S.
    Custic, I.
    Niemiec, J.
    Guio-Carrion, A.
    Hasenfuss, S. C.
    Eger, A.
    Mueller, M.
    Beug, H.
    Wagner, E. F.
    [J]. CELL DEATH AND DIFFERENTIATION, 2015, 22 (02) : 336 - 350
  • [4] RETRACTED: Over-Expression of FoxM1 Leads to Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype in Pancreatic Cancer Cells (Retracted article. See vol. 117, pg. 1963, 2016)
    Bao, Bin
    Wang, Zhiwei
    Ali, Shadan
    Kong, Dejuan
    Banerjee, Sanjeev
    Ahmad, Aamir
    Li, Yiwei
    Azmi, Asfar S.
    Miele, Lucio
    Sarkar, Fazlul H.
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (09) : 2296 - 2306
  • [5] SUMOylation in carcinogenesis
    Bettermann, Kira
    Benesch, Martin
    Weis, Serge
    Haybaeck, Johannes
    [J]. CANCER LETTERS, 2012, 316 (02) : 113 - 125
  • [6] Regulation of Epithelial-Mesenchymal Transition through SUMOylation of Transcription Factors
    Bogachek, Maria V.
    De Andrade, James P.
    Weigel, Ronald J.
    [J]. CANCER RESEARCH, 2015, 75 (01) : 11 - 15
  • [7] The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?
    Brabletz, Simone
    Brabletz, Thomas
    [J]. EMBO REPORTS, 2010, 11 (09) : 670 - 677
  • [8] Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer
    Bronsert, Peter
    Kohler, Ilona
    Timme, Sylvia
    Kiefer, Selina
    Werner, Martin
    Schilling, Oliver
    Vashist, Yogesh
    Makowiec, Frank
    Brabletz, Thomas
    Hopt, Ulrich T.
    Bausch, Dirk
    Kulemann, Birte
    Keck, Tobias
    Wellner, Ulrich E.
    [J]. SURGERY, 2014, 156 (01) : 97 - 108
  • [9] ZEB proteins link cell motility with cell cycle control and cell survival in cancer
    Browne, Gareth
    Sayan, A. Emre
    Tulchinsky, Eugene
    [J]. CELL CYCLE, 2010, 9 (05) : 886 - 891
  • [10] Phosphorylation Regulates Functions of ZEB1 Transcription Factor
    Candelaria Llorens, M.
    Lorenzatti, Guadalupe
    Cavallo, Natalia L.
    Vaglienti, Maria V.
    Perrone, Ana P.
    Carenbauer, Anne L.
    Darling, Douglas S.
    Cabanillas, Ana M.
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (10) : 2205 - 2217
12345678910