Efficiency of Transplantation of Human Placental/Umbilical Blood Cells to Rats with Severe Spinal Cord Injury

被引：8
作者：
Ryabov, S. I. [1 ]
Zvyagintseva, M. A. [1 ]
Pavlovich, E. R. [1 ]
Smirnov, V. A. [1 ]
Grin', A. A. [1 ]
Chekhonin, V. P. [2 ]
机构：
[1] Minist Hlth Russian Federat, Moscow, Russia
[2] Minist Hlth Russian Federat, VP Serbskii State Res Ctr Social & Forens Psychia, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 01期
关键词：
severe spinal cord injury; umbilical blood cells; cell therapy; STEM-CELLS; TRAUMA; TESTS;
D O I：
10.1007/s10517-014-2498-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of a single intravenous injection of human umbilical blood were studied on the model of severe spinal cord contusion injury in rats. Rats receiving no umbilical blood (spontaneous recovery) served as the control. All rats exhibited pronounced hind limb paraplegia and autonomic dysfunction of pelvic organs after the injury. Recovery of the hind limb function was evaluated by loading tests and locomotor activity testing in the open field using BBB score for open-field testing. Testing was carried out weekly for 8 weeks after the injury. Open-field testing showed a significant (p < 0.05) increase of the rate and volume of the hind limb motor activity recovery in the groups receiving umbilical blood infusions.
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收藏
页码：85 / 88
页数：4
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