Synthesis, characterization, cytotoxicity, and molecular docking studies of ampyrone-based transition metal complexes

被引：20

作者：

Azam, Mohammad ^{[1
]}

Wabaidur, Saikh Mohammad ^{[1
]}

Alam, Mahboob ^{[2
]}

Khan, Zahid ^{[3
]}

Alanazi, Ibrahim O. ^{[4
]}

Al-Resayes, Saud I. ^{[1
]}

Moon, Il Soo ^{[5
]}

Rajendra ^{[6
]}

机构：

[1] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[2] Dongguk Univ, Div Chem & Biotechnol, 123 Dongdae Ro, Gyeongju, South Korea

[3] King Saud Univ, Genome Res Chair, Dept Biochem, Coll Sci, Riyadh, Saudi Arabia

[4] King Abdulaziz City Sci & Technol, Natl Biotechnol Ctr, POB 6086, Riyadh, Saudi Arabia

[5] Dongguk Univ, Dept Anat, Coll Med, Gyeongju 38066, South Korea

[6] Banasthali Vidyapith, Dept Chem, Banasthali 304022, Rajasthan, India

来源：

TRANSITION METAL CHEMISTRY | 2021年 / 46卷 / 01期

关键词：

PYRAZOLE; PERSPECTIVE;

D O I：

10.1007/s11243-020-00422-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel series of mononuclear transition metal complexes, [Cu(L)Cl]1, [Zn(L)Cl]2, [Pd(L)Cl]3, [Cd(L)I]4, [Pt(L)Cl]5, and [Hg(L)Cl]6, was constructed from a pyrazole-derived Schiff ligand,HL, and characterized by physicochemical and spectroscopic methods. Fourier-transform infrared (FT-IR) spectral data showed the studied ligand to be tridentate and coordinated to the metal ions via ONO donor atoms, whereas powder X-ray diffraction (PXRD) analysis revealed the crystalline nature of all the complexes. The in vitro cytotoxicity of the studied ligand and its complexes were tested by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay against the human colorectal cancer cell lines HCT116 and HT29. The results suggested that the HCT116 cell line is highly sensitive to complex1with a half-maximal inhibitory concentration (IC50) of 45.6 mu M, while both cell lines tolerated complexes2and4better in comparison withHL. In addition, complex1with significant anticancer activity was analyzed by molecular docking studies to explore its binding efficacy to the cyclin-dependent kinase 2 active site.

引用

页码：65 / 71

页数：7

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