Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom

被引：41

作者：

Nakonechna, A. ^{[1
]}

Dore, P. ^{[1
]}

Dixon, T. ^{[2
]}

Khan, S. ^{[3
]}

Deacock, S. ^{[3
]}

Holding, S. ^{[1
]}

Abuzakouk, M. ^{[1
]}

机构：

[1] Hull & East Yorkshire NHS Hosp Trust, Hull Royal Infirm, Dept Immunol, Kingston Upon Hull, N Humberside, England

[2] Liverpool Royal & Broadgreen Univ NHS Trust Hosp, Allergy Clin, Liverpool, Merseyside, England

[3] Frimley Pk Hosp NHS Fdn Trust, Dept Immunol, Frimley, England

来源：

ALLERGOLOGIA ET IMMUNOPATHOLOGIA | 2014年 / 42卷 / 01期

关键词：

Chlorhexidine; Anaphylaxis; Specific IgE; Mast cell tryptase; ANAPHYLAXIS; IGE; ANTIBODIES; ANESTHESIA; HISTAMINE;

D O I：

10.1016/j.aller.2012.08.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Chlorhexidine is widely used as an antiseptic agent. It is a potentially allergenic substance that can cause severe hypersensitivity reactions. Objective: We describe six patients who had anaphylactic reactions attributed to chlorhexidine during surgery. These patients were exposed to chlorhexidine in gels, swabs and catheters. Materials and methods: Six patients from three UK centres with clinical history suggestive of anaphylaxis during surgery are reported. Detailed history, review of case notes, determination of chlorhexidine specific IgE, mast cell tryptase and skin tests were performed. Results: On detailed assessment five of six patients demonstrated a previous history of reactions on re-exposure to chlorhexidine. All six patients had elevated specific IgE to chlorhexidine. Skin prick test with chlorhexidine was performed in four of the six patients and was found to be positive. Conclusion: Immediate hypersensitivity to chlorhexidine appears to be common but underreported in the UK. We recommend that centres investigating patients with reactions during anaesthesia and surgery should routinely include testing for chlorhexidine allergy. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.

引用

页码：44 / 49

页数：6

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