Two new noroleanane-type triterpenoid saponins from the stems of Stauntonia chinensis

被引：7

作者：

Feng, Tong-Tong ^{[1
,2
]}

Fu, Hui-Zheng ^{[1
]}

Yang, Yi-Sheng ^{[1
]}

Zhou, Zhi-Qiang ^{[1
]}

Dai, Mian ^{[1
,2
]}

Bi, Hong-Yu ^{[1
,2
]}

Wang, Dong ^{[1
,2
]}

机构：

[1] Jiangxi Prov Inst Drug Control, Jiangxi Prov Engn Res Ctr Drug & Med Device Qual, Nanchang, Jiangxi, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Nanchang, Jiangxi, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Stauntonia chinensis; Lardizabalaceae; noroleanane-type triterpenoids; cytotoxic activity; LEAVES;

D O I：

10.1080/14786419.2018.1470515

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new noroleanane-type triterpenoid saponins, 3 beta,20 alpha,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-beta-L-fucopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (1) and 3 beta,20 alpha,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-beta-D-glucopyranosyl-(1 -> 2)-[alpha-L-arabinopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (2) were isolated from the stems of Stauntonia chinensis DC., together with three known compounds, brachyantheraoside B-2 (3), eupteleasaponin x2167; (4) and fargoside B (5). Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1 and 2 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1 and 2 showed moderate cytotoxic activities toward the tested cell lines with IC50 values ranging from 12.71 to 32.04 mu M. [GRAPHICS] .

引用

页码：1269 / 1276

页数：8

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