Omalizumab Therapy for Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis: A Synthesis of Published Evidence

被引：50
作者：
Tanou, Kalliopi [1 ,2 ]
Zintzaras, Elias [3 ,4 ]
Kaditis, Athanasios G. [1 ,2 ]
机构：
[1] Univ Athens, Sch Med, Dept Pediat 1, Pediat Pulmonol Unit, GR-11527 Athens, Greece
[2] Aghia Sophia Childrens Hosp, Athens, Greece
[3] Tufts Univ, Sch Med, Tufts Med Ctr, Ctr Clin Evidence Synth,Inst Clin Res & Hlth Poli, Boston, MA 02111 USA
[4] Univ Thessaly, Sch Med, Dept Biomath, Larisa, Greece
来源：
PEDIATRIC PULMONOLOGY | 2014年 / 49卷 / 05期
关键词：
ABPA; A; fumigatus; anti-IgE; ANTI-IGE ANTIBODY; ABPA; CF;
D O I：
10.1002/ppul.22937
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is treated with corticosteroids. Since elevated IgE is a cardinal abnormality, anti-IgE has been used sporadically as adjuvant treatment. In eight case reports, 13 children with CF and ABPA received anti-IgE resulting in improved FEV1, fewer respiratory symptoms and decreased corticosteroid use. Pediatr Pulmonol. 2014; 49:503-507. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：503 / 507
页数：5
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