Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe

被引：94

作者：

Li, Rui ^{[1
,2
]}

Zhu, Xinyi ^{[1
]}

Yin, Shufei ^{[1
]}

Niu, Yanan ^{[1
,2
]}

Zheng, Zhiwei ^{[1
]}

Huang, Xin ^{[1
]}

Wang, Baoxi ^{[1
]}

Li, Juan ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2014年 / 6卷

基金：

中国国家自然科学基金;

关键词：

intervention; plasticity; aging; fMRI; functional connectivity; MILD COGNITIVE IMPAIRMENT; MODE NETWORK ACTIVITY; VERBAL FLUENCY; ALZHEIMERS-DISEASE; BRAIN; MEMORY; AGE; PLASTICITY; HIPPOCAMPUS; VARIABILITY;

D O I：

10.3389/fnagi.2014.00039

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. Results showed that the intervention selectively affected resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe. Moreover, the strength of resting-state functional connectivity between these regions correlated with individual cognitive performance. Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age.

引用

页数：13

共 73 条

[1] Personality Is Reflected in the Brain's Intrinsic Functional Architecture [J].

Adelstein, Jonathan S. ;

Shehzad, Zarrar ;

Mennes, Maarten ;

DeYoung, Colin G. ;

Zuo, Xi-Nian ;

Kelly, Clare ;

Margulies, Daniel S. ;

Bloomfield, Aaron ;

Gray, Jeremy R. ;

Castellanos, F. Xavier ;

Milham, Michael P. .

PLOS ONE, 2011, 6 (11)

[2] The Resting Human Brain and Motor Learning [J].

Albert, Neil B. ;

Robertson, Edwin M. ;

Miall, R. Chris .

CURRENT BIOLOGY, 2009, 19 (12) :1023-1027

[3] Disruption of large-scale brain systems in advanced aging [J].

Andrews-Hanna, Jessica R. ;

Snyder, Abraham Z. ;

Vincent, Justin L. ;

Lustig, Cindy ;

Head, Denise ;

Raichle, Marcus E. ;

Buckner, Randy L. .

NEURON, 2007, 56 (05) :924-935

[4]

[Anonymous], 1998, ADM NORMS COMMENTARY

[5]

[Anonymous], NEUROBIOL AGING

[6]

[Anonymous], AFFECT SOCIAL THINKI

[7]

[Anonymous], 1986, Acta PsychologicaSinica

[8] Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders [J].

Arenaza-Urquijo, Eider M. ;

Landeau, Brigitte ;

La Joie, Renaud ;

Mevel, Katell ;

Mezenge, Florence ;

Perrotin, Audrey ;

Desgranges, Beatrice ;

Bartres-Faz, David ;

Eustache, Francis ;

Chetelat, Gael .

NEUROIMAGE, 2013, 83 :450-457

[9] NEURONAL LOSS, NEUROFIBRILLARY TANGLES AND GRANULOVACUOLAR DEGENERATION IN HIPPOCAMPUS WITH AGING AND DEMENTIA - QUANTITATIVE STUDY [J].

BALL, MJ .

ACTA NEUROPATHOLOGICA, 1977, 37 (02) :111-118

[10] Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging [J].

Bastin, Christine ;

Yakushev, Igor ;

Bahri, Mohamed Ali ;

Fellgiebel, Andreas ;

Eustache, Francis ;

Landeau, Brigitte ;

Scheurich, Armin ;

Feyers, Dorothee ;

Collette, Fabienne ;

Chetelat, Gael ;

Salmon, Eric .

NEUROIMAGE, 2012, 63 (02) :713-722

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