Predicting Visual Sensitivity in Retinal Prosthesis Patients

被引：80

作者：

Horsager, Alan ^{[1
,2
]}

Greenwald, Scott H. ^{[4
]}

Weiland, James D. ^{[3
]}

Humayun, Mark S. ^{[3
]}

Greenberg, Robert J. ^{[4
]}

McMahon, Matthew J. ^{[4
]}

Boynton, Geoffrey M. ^{[5
]}

Fine, Ione ^{[5
]}

机构：

[1] Univ So Calif, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA

[2] Univ So Calif, Grad Program Neurosci, Los Angeles, CA 90089 USA

[3] Univ So Calif, Doheny Eye Inst, Los Angeles, CA 90089 USA

[4] Second Sight Med Prod Inc, Sylmar, CA USA

[5] Univ Washington, Dept Psychol, Seattle, WA 98195 USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2009年 / 50卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ELECTRICAL-STIMULATION; GANGLION-CELLS; PERCEPTUAL THRESHOLDS; RETINITIS-PIGMENTOSA; CONTRAST ADAPTATION; TEMPORAL CONTRAST; REMOTE-CONTROL; RESPONSES; PATTERNS; NEURONS;

D O I：

10.1167/iovs.08-2595

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. With the long-term goal of restoring functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects were implanted chronically with epiretinal prostheses consisting of two-dimensional electrode arrays that directly stimulated cells of the neural retina. METHODS. Psychophysical techniques were used to measure the brightness of electrically generated percepts on single electrodes using a variety of electrical stimulation patterns. RESULTS. It was possible to predict the sensitivity of the human visual system to a wide variety of retinal electrical stimulation patterns using a simple and biologically plausible model. CONCLUSIONS. This is the first study to demonstrate that, on the single-electrode level, retinal electrical stimulation in humans can produce visual qualia that are predictable using a quantitative model, a prerequisite for a successful retinal prosthesis. (ClinicalTrials.gov number, NCT00279500.) (Invest Ophthalmol Vis Sci. 2009; 50: 1483-1491) DOI:10.1167/iovs.08-2595

引用

页码：1483 / 1491

页数：9

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