A convenient two-step one-pot synthesis of alkylthiophosphoramidates derivatives

被引：2

作者：

Miao, ZW ^{[1
]}

Fu, H ^{[1
]}

Han, B ^{[1
]}

Chen, Y ^{[1
]}

Zhao, YF ^{[1
]}

机构：

[1] Tsing Hua Univ, Sch Life Sci & Engn, Dept Chem, Minist Educ,Key Lab Bioorgan Phosphorous Chem, Beijing 100084, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2002年 / 177卷 / 03期

基金：

中国国家自然科学基金;

关键词：

alkylthiophosphoramidates derivatives; amino acid ester; hydrolysis; O-isopropyl phosphorodichloridothioate; P-31 NMR spectroscopy;

D O I：

10.1080/10426500210257

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

N-thiophosphonylamino groups have been greatly overlooked as potentially potent, transition-state analogues, or tetrahedral-intermediate inhibitors of metalloproteases. Alkylthiophosphoramidates derivatives were synthesized by reaction of O-isopropyl phosphorodichloridothioate with an amino acid ester followed by hydrolysis in 2M NH4OH. The reaction was monitored by P-31 NMR spectroscopy.

引用

页码：641 / 646

页数：6

共 9 条

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