Sequencing the transcriptional network of androgen receptor in prostate cancer

被引：9

作者：

Chng, Kern Rei ^{[1
,4
]}

Cheung, Edwin ^{[1
,2
,3
]}

机构：

[1] ASTAR, Canc Biol & Pharmacol, Genome Inst Singapore, Singapore 138672, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

[3] Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

[4] Natl Univ Singapore, Grad Sch Integrat Sci & Engn, Singapore 117573, Singapore

来源：

CANCER LETTERS | 2013年 / 340卷 / 02期

关键词：

Chromatin immunoprecipitation; High-throughput sequencing; Androgen receptor; Prostate cancer; Transcriptional network; GROUP PROTEIN EZH2; HISTONE DEACETYLASE-1; GENE FUSIONS; E-CADHERIN; MESENCHYMAL TRANSITION; EXPRESSION; POLYCOMB; BINDING; PROGRESSION; ACTIVATION;

D O I：

10.1016/j.canlet.2012.11.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The progression of prostate cancer is largely dependent on the activity of the androgen receptor (AR), which in turn, correlates with the net output of the AR transcriptional regulatory network. A detailed and thorough understanding of the AR transcriptional regulatory network is therefore critical in the strategic manipulation of AR activity for the targeted eradication of prostate cancer cells. In this mini-review, we highlight some of the novel and unexpected mechanistic and functional insights of the AR transcriptional network derived from recent targeted sequencing (ChIP-Seq) studies of AR and its coregulatory factors in prostate cancer cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：254 / 260

页数：7

共 67 条

[1] Cell- and gene-specific regulation of primary target genes by the androgen receptor
Bolton, Eric C.
So, Alex Y.
Chaivorapol, Christina
Haqq, Christopher M.
Li, Hao
Yamamoto, Keith R.
[J]. GENES & DEVELOPMENT, 2007, 21 (16) : 2005 - 2017
[2] Contribution of the androgen receptor to prostate cancer predisposition and progression
Buchanan, G
Irvine, RA
Coetzee, GA
Tilley, WD
[J]. CANCER AND METASTASIS REVIEWS, 2001, 20 (3-4) : 207 - 223
[3] Repression of E-cadherin by the polycomb group protein EZH2 in cancer
Cao, Q.
Yu, J.
Dhanasekaran, S. M.
Kim, J. H.
Mani, R-S
Tomlins, S. A.
Mehra, R.
Laxman, B.
Cao, X.
Yu, J.
Kleer, C. G.
Varambally, S.
Chinnaiyan, A. M.
[J]. ONCOGENE, 2008, 27 (58) : 7274 - 7284
[4] Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
Carver, Brett S.
Tran, Jennifer
Gopalan, Anuradha
Chen, Zhenbang
Shaikh, Safa
Carracedo, Arkaitz
Alimonti, Andrea
Nardella, Caterina
Varmeh, Shohreh
Scardino, Peter T.
Cordon-Cardo, Carlos
Gerald, William
Pandolfi, Pier Paolo
[J]. NATURE GENETICS, 2009, 41 (05) : 619 - 624
[5] Role of the TMPRSS2-ERG gene fusion in prostate cancer
Chinnaiyan, Arul M.
[J]. NEOPLASIA, 2008, 10 (02): : 177 - U23
[6] A transcriptional repressor co-regulatory network governing androgen response in prostate cancers
Chng, Kern Rei
Chang, Cheng Wei
Tan, Si Kee
Yang, Chong
Hong, Shu Zhen
Sng, Noel Yan Wei
Cheung, Edwin
[J]. EMBO JOURNAL, 2012, 31 (12) : 2810 - 2823
[7] Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
Core, Leighton J.
Waterfall, Joshua J.
Lis, John T.
[J]. SCIENCE, 2008, 322 (5909) : 1845 - 1848
[8] A CONTROLLED TRIAL OF LEUPROLIDE WITH AND WITHOUT FLUTAMIDE IN PROSTATIC-CARCINOMA
CRAWFORD, ED
EISENBERGER, MA
MCLEOD, DG
SPAULDING, JT
BENSON, R
DORR, FA
BLUMENSTEIN, BA
DAVIS, MA
GOODMAN, PJ
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (07) : 419 - 424
[9] Expression and function of androgen receptor coactivators in prostate cancer
Culig, Z
Comuzzi, B
Steiner, H
Bartsch, G
Hobisch, A
[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 92 (04) : 265 - 271
[10] The role of androgens and the androgen receptor in prostate cancer
Debes, JD
Tindall, DJ
[J]. CANCER LETTERS, 2002, 187 (1-2) : 1 - 7

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