Monocytic Myeloid-Derived Suppress Cells Restore Adipogenic Bone Marrow Microenvironment in Aplastic Anemia By Inhibiting Intra-BM CD8+ T Cells Proliferation

被引:0
|
作者
Qu, Ying [1 ]
Sun, Zhengxu [1 ]
Yuan, Yan [1 ]
Wang, Fen [1 ]
Wu, Kunpeng [1 ]
Cheng, Yunfeng [1 ]
Jiang, Hua [2 ]
Chen, Tong [1 ]
机构
[1] Fudan Univ, Huashan Hosp, Dept Hematol, Shanghai, Peoples R China
[2] Fudan Univ, OB&GYN Hosp, Dept Gynecol, Shanghai, Peoples R China
关键词
D O I
10.1182/blood-2019-125059
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1211
引用
收藏
页数:4
相关论文
共 50 条
  • [31] Negative impact of myeloid-derived suppressor cells on CD8 effector T cell trafficking within the tumor microenvironment
    Ku, Amy
    Muhitch, Jason
    Abrams, Scott
    Evans, Sharon
    JOURNAL OF IMMUNOLOGY, 2014, 192
  • [32] Monocytic myeloid-derived suppressor cells isolated from mice with colitis actively suppress CD4+T cell functions in vitro.
    Kurmaeva, Elvira
    Berney, Seth
    Ostanin, Dmitry
    JOURNAL OF IMMUNOLOGY, 2011, 186
  • [33] Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
    Lesokhin, Alexander M.
    Hohl, Tobias M.
    Kitano, Shigehisa
    Cortez, Czrina
    Hirschhorn-Cymerman, Daniel
    Avogadri, Francesca
    Rizzuto, Gabrielle A.
    Lazarus, John J.
    Pamer, Eric G.
    Houghton, Alan N.
    Merghoub, Taha
    Wolchok, Jedd D.
    CANCER RESEARCH, 2012, 72 (04) : 876 - 886
  • [34] Exosomes Derived From T Regulatory Cells Suppress CD8+ Cytotoxic T Lymphocyte Proliferation and Prolong Liver Allograft Survival
    Chen, Liang
    Huang, Hanfei
    Zhang, Weixin
    Ding, Feifan
    Fan, Zhenlei
    Zeng, Zhong
    MEDICAL SCIENCE MONITOR, 2019, 25 : 4877 - 4884
  • [35] Transcript profile of CD4 and CD8 T cells from the bone marrow of acquired aplastic anemia patients.
    Zeng, WH
    Chen, GB
    Kajigaya, S
    Risitano, AM
    Nunez, O
    Young, NS
    BLOOD, 2003, 102 (11) : 512A - 512A
  • [36] Oligoclonal Expansion of Effector Memory CD8+CD57+T Cells May Sustain Bone Marrow Destruction in Aplastic Anemia
    Giudice, Valentina
    Feng, Xingmin
    Lin Zenghua
    Ibanez, Maria del Pilar Fernandez
    Keyvanfar, Keyvan
    Selleri, Carmine
    Young, Neal S.
    BLOOD, 2016, 128 (22)
  • [37] Memory CD8+ T cells colocalize with IL-7+ stromal cells in bone marrow and rest in terms of proliferation and transcription
    Alp, Oezen Sercan
    Durlanik, Sibel
    Schulz, Daniel
    McGrath, Mairi
    Gruen, Joachim R.
    Bardua, Marcus
    Ikuta, Koichi
    Sgouroudis, Evridiki
    Riedel, Rene
    Zehentmeier, Sandra
    Hauser, Anja E.
    Tsuneto, Motokazu
    Melchers, Fritz
    Tokoyoda, Koji
    Chang, Hyun-Dong
    Thiel, Andreas
    Radbruch, Andreas
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (04) : 975 - 987
  • [38] ALLOGENEIC BONE MARROW TRANSPLANTATION INDUCES MYELOID-DERIVED SUPPRESSOR CELLS (MDSCS), WHICH PREVENT T CELL PROLIFERATION IN VITRO BUT ARE UNABLE TO SUPPRESS T CELL FUNCTIONS AND GVHD IN VIVO
    Messmann, J.
    Leithaeuser, F.
    Lutz, M. B.
    Debatin, K. M.
    Strauss, G.
    HAEMATOLOGICA, 2014, 99 : 536 - 536
  • [39] Myeloid-Derived Suppressor Cell Regulation of PD-1 Expression on, and Longevity of, Human CD8+ T Cells.
    Kim, Younri-June
    Aisen, Adam T.
    Broxmeyer, Hal E.
    BLOOD, 2008, 112 (11) : 889 - 890
  • [40] CD8+ T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer
    Zhuang, Yuan
    Peng, Liu-Sheng
    Zhao, Yong-Liang
    Shi, Yun
    Mao, Xu-Hu
    Chen, Weisan
    Pang, Ken C.
    Liu, Xiao-Fei
    Liu, Tao
    Zhang, Jin-Yu
    Zeng, Hao
    Liu, Kai-Yun
    Guo, Gang
    Tong, Wen-De
    Shi, Yan
    Tang, Bin
    Li, Na
    Yu, Shu
    Luo, Ping
    Zhang, Wei-Jun
    Lu, Dong-Shui
    Yu, Pei-Wu
    Zou, Quan-Ming
    GASTROENTEROLOGY, 2012, 143 (04) : 951 - +