Management of supine hypertension in patients with neurogenic orthostatic hypotension: scientific statement of the American Autonomic Society, European Federation of Autonomic Societies, and the European Society of Hypertension

被引：82

作者：

Jordan, Jens ^{[1
,2
,3
]}

Fanciulli, Alessandra ^{[4
]}

Tank, Jens ^{[1
,2
,3
]}

Calandra-Buonaura, Giovanna ^{[5
]}

Cheshire, William P. ^{[7
]}

Cortelli, Pietro ^{[5
,6
]}

Eschlboeck, Sabine ^{[4
]}

Grassi, Guido ^{[8
,9
]}

Hilz, Max J. ^{[10
,11
]}

Kaufmann, Horacio ^{[12
]}

Lahrmann, Heinz

Mancia, Giuseppe ^{[13
]}

Mayer, Gert ^{[14
]}

Norcliffe-Kaufmann, Lucy ^{[12
]}

Pavy-Le Traon, Anne ^{[15
,16
]}

Raj, Satish R. ^{[17
,18
]}

Robertson, David ^{[18
]}

Rocha, Isabel ^{[19
]}

Reuter, Hannes ^{[20
,21
]}

Struhal, Walter ^{[22
]}

Thijs, Roland D. ^{[23
,24
]}

Tsioufis, Konstantinos P. ^{[25
]}

van Dijk, J. Gert ^{[24
]}

Wenning, Gregor K. ^{[4
]}

Biaggioni, Italo ^{[18
]}

机构：

[1] German Aerosp Ctr DLR, Inst Aerosp Med, Cologne, Germany

[2] Univ Cologne, Chair Aerospace Med, Cologne, Germany

[3] Univ Cologne, Univ Hypertens Ctr, Cologne, Germany

[4] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria

[5] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

[6] IRCCS, Inst Neurol Sci Bologna, Bologna, Italy

[7] Mayo Clin, Dept Neurol, Jacksonville, FL USA

[8] Univ Milano Bicocca, Clin Med, Milan, Italy

[9] Ist Ric Carattere Sci IRCCS Multimed, Sesto San Giovanni, Milan, Italy

[10] Univ Klinikum Erlangen, Dept Neurol, Erlangen, Germany

[11] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA

[12] NYU, Dysauton Ctr, Dept Neurol, Sch Med, New York, NY USA

[13] Ctr Fisiol Clin Ipertensione, Milan, Italy

[14] Innsbruck Med Univ, Dept Internal Med 4, Innsbruck, Austria

[15] Univ Hosp Toulouse, Dept Neurol, French Reference Ctr Multiple Syst Atrophy, Toulouse, France

[16] UMR INSERM 1048, Toulouse, France

[17] Univ Calgary, Dept Cardiac Sci, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada

[18] Vanderbilt Univ, Med Ctr, Div Clin Pharmacol, Dept Med, Nashville, TN USA

[19] Univ Lisbon, Inst Physiol, Fac Med, Lisbon, Portugal

[20] Evangelisches Klinikum, Dept Internal Med & Cardiol, Cologne, Germany

[21] Univ Hosp Cologne, Dept Internal Med 3, Cardiac Ctr, Cologne, Germany

[22] Karl Landsteiner Univ Hlth Sci, Site Tulln, Dept Neurol, Tulln, Austria

[23] Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands

[24] Leiden Univ Med Ctr, Dept Neurol, Leiden, Netherlands

[25] Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Dept Cardiol 1, Athens, Greece

来源：

JOURNAL OF HYPERTENSION | 2019年 / 37卷 / 08期

基金：

美国国家卫生研究院;

关键词：

autonomic failure; neuropathy; orthostatic hypotension; supine hypertension; BLOOD-PRESSURE; ANGIOTENSIN-II; FAILURE; ASSOCIATION; CLONIDINE; MIDODRINE; EFFICACY; BALANCE; PLACEBO;

D O I：

10.1097/HJH.0000000000002078

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Supine hypertension commonly occurs in patients with neurogenic orthostatic hypotension due to autonomic failure. Supine hypertension promotes nocturnal sodium excretion and orthostatic hypotension, thus, interfering with quality of life. Perusal of the literature on essential hypertension and smaller scale investigations in autonomic failure patients also suggest that supine hypertension may predispose to cardiovascular and renal disease. These reasons provide a rationale for treating supine hypertension. Yet, treatment of supine hypertension, be it through nonpharmacological or pharmacological approaches, may exacerbate orthostatic hypotension when patients get up during the night. Fall-related complications may occur. More research is needed to define the magnitude of the deleterious effects of supine hypertension on cardiovascular, cerebrovascular, and renal morbidity and mortality. Integration of more precise cardiovascular risk assessment, efficacy, and safety data, and the prognosis of the underlying condition causing autonomic failure is required for individualized management recommendations.

引用

页码：1541 / 1546

页数：6

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