Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium

被引：59

作者：

Zaman, Rysa ^{[1
,2
,3
]}

Hamidzada, Homaira ^{[1
,2
,3
]}

Epelman, Slava ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Hlth Network, Toronto Gen Hosp, Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Ted Rogers Ctr Heart Res, Translat Biol & Engn Program, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[5] Toronto Gen Hosp, Peter Munk Cardiac Ctr, Toronto, ON, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2021年 / 68卷

基金：

加拿大健康研究院;

关键词：

CAVITY MACROPHAGES; HEART-FAILURE; REVEALS; MODEL; POLARIZATION; INFLAMMATION; PROGRESSION; DEFICIENCY; MECHANISMS; CONTRIBUTE;

D O I：

10.1016/j.coi.2020.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cardiac macrophages maintain homeostasis and orchestrate response to disease. Utilization of genetic fate-mapping and single-cell RNA sequencing shifted the paradigm of macrophage heterogeneity from the canonical M1/M2 classification in favour of a nuanced approach that reconciles divergent origins, lifecycles, and transcriptional states. Here, we provide a conceptual framework to assess cardiac macrophage complexity that integrates transcriptional and functional heterogeneity that tracks with subset-specific markers (TIMD4 and CCR2). Our goal is to provide a starting point for researchers to dissect the functions of known resident cardiac macrophage subpopulations. We discuss recent advances and limitations in our understanding of cardiac macrophage diversity in ischemic injury, hypertension and myocarditis.

引用

页码：54 / 63

页数：10

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