The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)

被引：18

作者：

Yuan, Zuoqing ^{[1
]}

Zhang, Jianyong ^{[1
]}

Tu, Changchao ^{[1
]}

Wang, Zhijing ^{[1
]}

Xin, Wenpeng ^{[1
]}

机构：

[1] Shandong Univ Technol, Sch Life Sci, 12 Zhangzhou Rd, Zibo 255049, Shandong, Peoples R China

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2016年 / 127卷

基金：

中国国家自然科学基金;

关键词：

Dugesia japonica; Perfluorooctanoic acid (PFOA); Anthocyanins; Mitochondria; Total antioxidant capacity; Enzyme activities; MITOCHONDRIAL PERMEABILITY TRANSITION; PERFLUOROALKYL ACIDS; ANTIOXIDANT ACTIVITY; APOPTOSIS; TARGET; CELLS; PORE;

D O I：

10.1016/j.ecoenv.2016.01.019

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15 mg/L and anthocyanins at 10 or 20 mg/L were individually and simultaneously administered to plinarians for up to 10 d. The results showed PFOA treatment induced an increase in mitochondrial permeability transition pore opening and a decrease antioxidant capacity and enzyme activities. In anthocyanin treated animals, the activity of succinate dehydrogenase, cytochrome oxidase and monoamine oxidase increased, but mitochondrial permeability transition pore opening decreased and total antioxidant capacity increased. An improvement in above mentioned physiological and biochemical parameters was found in the combined PFOA and anthocyanin treated animals, in a dose-dependent manner. Anthocyanins attenuated the PFOA induced toxicity; antioxidant capacity and enzyme activities are involved in the protective mechanism of anthocyanins. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：170 / 174

页数：5

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