RETRACTED: Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats (Retracted article. See vol. 21, pg. 761, 2022)

被引:28
作者
Yi, Min [1 ]
Dai, Xingping [1 ]
Li, Qiuxia [1 ]
Xu, Xia [1 ]
Chen, Yanyi [1 ]
Wang, Dongsheng [1 ]
机构
[1] Cent South Univ, Xiangya Hosp, Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China
关键词
Long non-coding RNA CRNDE; Traumatic brain injury; nerve repair; LONG NONCODING RNAS; CORTICAL INJURY; SYSTEM; MECHANISMS; EXPRESSION; RESPONSES; PROFILE; ROLES; CELLS; MICE;
D O I
10.1080/15384101.2019.1647024
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective: Long non-coding RNAs (lncRNAs) have recently been demonstrated to be involved in craniocerebral disease, but their expression in traumatic brain injury (TBI) is still unearthed. Therefore, we aimed to elucidate the effect of lncRNA CRNDE on TBI. Methods: Firstly, CRNDE expression was determined in serum of TBI patients and healthy controls. The TBI rat model was established based on Feeney's freefall impact method. The modeled rats were injected with siRNA against CRNDE, and the rats' neurobehavioral function were measured. Besides, expression of inflammatory factors, size, shape and number of hippocampal neurons, neuron apoptosis, Beclin I, LC3-I, LC3-II, glial fibrillary acidic protein (GFAP), BrdU, nerve growth factor (NGF), nestin, and neuronal nuclei (NeuN) expression were detected through different methods. Results: In TBI, CRNDE was found to be upregulated. Downregulated CRNDE improved neurobehavioral function, repressed expression of neuroinflammatory factors, elevated number of Nissl bodies, as well as restricted neuronal apoptosis and autophagy in TBI rats. Besides, downregulated CRNDE also promoted expression of GFAP, BrdU, NGF, nestin, and NeuN, thus induced the differentiation of neurons and the directional growth and regeneration of nerve fibers. Conclusion: Altogether, we found that silencing of CRNDE might be able to promote the nerve repair after TBI in rats.
引用
收藏
页码:2332 / 2343
页数:12
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