A new cation exchange resin designed for the removal of monoclonal antibody aggregates using flow-through frontal chromatography

被引:0
|
作者
Stone, Matthew [1 ]
Cotoni, Kristen [1 ]
Stoner, Jayson [1 ]
Menstell, Peter [1 ]
机构
[1] MilliporeSigma, Arlington, MA USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
70
引用
收藏
页数:1
相关论文
共 40 条
  • [11] Exploration of fib er-base d cation exchange adsorbents for the removal of monoclonal antibody aggregates
    Winderl, Johannes
    Neumann, Eric
    Hubbuch, Jurgen
    JOURNAL OF CHROMATOGRAPHY A, 2021, 1654 (1654)
  • [12] Separation of closely related monoclonal antibody charge variant impurities using poly(ethylenimine)-grafted cation-exchange chromatography resin
    Ganesh T. Sivanathan
    Hanuman Mallubhotla
    Satyanarayana V. Suggala
    Manikanta Sriharsha Tholu
    3 Biotech, 2022, 12
  • [13] Separation of closely related monoclonal antibody charge variant impurities using poly(ethylenimine)-grafted cation-exchange chromatography resin
    Sivanathan, Ganesh T.
    Mallubhotla, Hanuman
    Suggala, Satyanarayana, V
    Tholu, Manikanta Sriharsha
    3 BIOTECH, 2022, 12 (11)
  • [14] Development of an acidic/neutral antibody flow-through polishing step using salt-tolerant anion exchange chromatography
    Kang, Yun
    Ambat, Rajesh
    Hall, Troii
    Sauffer, Matthew D.
    Ng, Stanley
    Healy-Fried, Martha L.
    Lee, Julia
    Adaelu, Josaih C.
    Holmes, William D.
    Emery, Warren
    Shanehsaz, Behnam
    Huebner, Amy
    Qi, Bo
    Chen, Richard
    Barry, Michael
    Ludwig, Dale L.
    Balderes, Paul
    Pharmaceutical Bioprocessing, 2015, 3 (08) : 477 - 487
  • [15] Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates
    Borg, Niklas
    Brodsky, Yan
    Moscariello, John
    Vunnum, Suresh
    Vedantham, Ganesh
    Westerberg, Karin
    Nilsson, Bernt
    JOURNAL OF CHROMATOGRAPHY A, 2014, 1359 : 170 - 181
  • [16] The prevention of an anomalous chromatographic behavior and the resulting successful removal of viruses from monoclonal antibody with an asymmetric charge distribution by using a membrane adsorber in highly efficient, anion-exchange chromatography in flow-through mode
    Masuda, Yumiko
    Ogino, Yuka
    Yamaichi, Kozo
    Takahashi, Yusuke
    Nonaka, Koichi
    Wakamatsu, Kaori
    BIOTECHNOLOGY PROGRESS, 2020, 36 (03)
  • [17] Characterization of the glycosylation state of a recombinant monoclonal antibody using weak cation exchange chromatography and mass spectrometry
    Gaza-Bulseco, Georgeen
    Bulseco, Ashley
    Chumsae, Chris
    Liu, Hongcheng
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 862 (1-2): : 155 - 160
  • [18] Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization
    Jing, Shu-Ying
    Gou, Jin-Xia
    Gao, Dong
    Wang, Hai-Bin
    Yao, Shan-Jing
    Lin, Dong-Qiang
    SEPARATION AND PURIFICATION TECHNOLOGY, 2020, 235 (235)
  • [19] Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS
    Ponniah, Gomathinayagam
    Kita, Adriana
    Nowak, Christine
    Neill, Alyssa
    Kori, Yekaterina
    Rajendran, Saravanamoorthy
    Liu, Hongcheng
    ANALYTICAL CHEMISTRY, 2015, 87 (17) : 9084 - 9092
  • [20] Simultaneous removal of leached protein-A and aggregates from monoclonal antibody using hydrophobic interaction membrane chromatography
    Yoo, Seung Mi
    Ghosh, Raja
    JOURNAL OF MEMBRANE SCIENCE, 2012, 390 : 263 - 269