A simple and one-pot multi-component reaction to the synthesis of methylenebisamides

被引:11
作者
Mohammadi, Bagher [1 ]
Khorrami, Bahareh Rezaei [1 ]
机构
[1] Payame Noor Univ, Dept Chem, Tehran 193953697, Iran
来源
MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 06期
关键词
Bisamide; Multi-component reaction; DMSO; Hydroxylamine hydrochloride; One pot; SYMMETRICAL N; N'-ALKYLIDENE BISAMIDES; SOLVENT-FREE CONDITIONS; BIOLOGICAL-ACTIVITY; EFFICIENT SYNTHESIS; DERIVATIVES; ACID; INHIBITORS; CATALYST; CHLORIDE; BLOCKS;
D O I
10.1007/s00706-017-2124-4
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This work described a simple and efficient method for the synthesis of some methylenebisamide derivatives. The reaction is carried out via a simple multi-component reaction between arylaldehydes, DMSO, and hydroxylamine hydrochloride. Short reaction times, excellent yields of products, inexpensive and readily available starting material, eco-friendly method, easy work-up, and high atom economy are the main advantages of this reaction. [GRAPHICS] .
引用
收藏
页码:1089 / 1092
页数:4
相关论文
共 33 条
  • [1] Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors
    Adla, Santosh Kumar
    Slavikova, Barbora
    Smidkova, Marketa
    Tloustova, Eva
    Svoboda, Martin
    Vyklicky, Vojtech
    Krausova, Barbora
    Hubalkova, Pavla
    Nekardova, Michaela
    Holubova, Kristina
    Vales, Karel
    Budesinsky, Milos
    Vyklicky, Ladislav
    Chodounska, Hana
    Kudova, Eva
    [J]. STEROIDS, 2017, 117 : 52 - 61
  • [2] RETROMODIFIED RESIDUES - SMALL PEPTIDES AND POLYMERS - INTERACTIONS, FORCE-FIELD PARAMETRIZATION AND CONFORMATIONAL-ANALYSES
    ALEMAN, C
    PUIGGALI, J
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (04) : 910 - 924
  • [3] p-Toluene Sulfonic Acid-Catalyzed, Solvent-Free Synthesis of Symmetrical Bisamides by Reaction Between Aldehydes and Amides
    Anary-Abbasinejad, Mohammad
    Mosslemin, Mohammad H.
    Hassanabadi, Alireza
    Safa, Safiyeh Tajik
    [J]. SYNTHETIC COMMUNICATIONS, 2010, 40 (15) : 2209 - 2214
  • [4] Eco-efficiency and scalable synthesis of bisamides in deep eutectic solvent
    Azizi, Najmedin
    Alipour, Masoumeh
    [J]. JOURNAL OF MOLECULAR LIQUIDS, 2015, 206 : 268 - 271
  • [5] Fernandez AH, 1996, SYNTHESIS-STUTTGART, P1299
  • [6] Galewicz-Walesa K, 2003, SYNTHESIS-STUTTGART, V58, P118
  • [7] Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
    Gao, Li Ming
    Matta, Jaime
    Rheingold, Arnold L.
    Melendez, Enrique
    [J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (26) : 4134 - 4139
  • [8] Peptidomimetic building blocks for drug discovery: An overview
    Goodman, M
    Shao, H
    [J]. PURE AND APPLIED CHEMISTRY, 1996, 68 (06) : 1303 - 1308
  • [9] SYNTHESIS AND EVALUATION OF AZAPEPTIDE-DERIVED INHIBITORS OF SERINE AND CYSTEINE PROTEASES
    GRAYBILL, TL
    ROSS, MJ
    GAUVIN, BR
    GREGORY, JS
    HARRIS, AL
    ATOR, MA
    RINKER, JM
    DOLLE, RE
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (11) : 1375 - 1380
  • [10] Boric acid Catalyzed Efficient Synthesis of Symmetrical N,N′-Alkylidene Bisamides
    Harichandran, G.
    Amalraj, S. David
    Shanmugam, P.
    [J]. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2011, 8 (01) : 298 - 305