Long non-coding RNA CCAT1 promotes the migration and invasion of prostate cancer PC-3 cells

被引：0
|
作者：
Chen, H. [1 ]
He, Y. [1 ]
Hou, Y. -S. [1 ]
Chen, D. -Q. [2 ]
He, S. -L. [1 ]
Cao, Y. -F. [1 ]
Wu, X. -M. [1 ]
机构：
[1] First Hosp Jiaxing, Dept Urol Surg, Jiaxing, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Med Oncol, Suzhou, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2018年 / 22卷 / 10期
关键词：
CCAT1; Prostate cancer; Proliferation; Migration; Invasion; POOR-PROGNOSIS; GASTRIC-CANCER; C-MYC; PROGRESSION; METASTASIS; EXPRESSION; APOPTOSIS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: To investigate the effect of long non-coding RNA CCAT1 on the proliferation, migration, and invasion of prostate cancer PC-3 cells. PATIENTS AND METHODS: The expression of CCAT1 was detected by Real-time PCR. The effect of CCAT1 down-regulation on the proliferation of PC-3 cells was observed by MTT assay. The regulatory of CCAT1 low-expression on the migration ability of PC-3 cells was investigated by transwell assay. The influence of decreased CCAT1 on the invasion ability of PC-3 cells was detected by Matrigel invasion assay. RESULTS: Increased CCAT1 was significantly related to lymph node metastasis in prostate cancer. Low-expression of CCAT1 could suppress cell proliferation. Knockdown of CCAT1 inhibited the migration of PC-3 cells. Down-regulation of CCAT1 attenuated the invasion of PC-3 cells. CONCLUSIONS: CCAT1 promoted the growth and the metastasis of prostate cancer. Our findings might provide a potential target for the diagnosis and treatment of prostate cancer.
引用
收藏
页码：2991 / 2996
页数：6
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