Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines

被引：73

作者：

Chen, CH

Wang, TL

Hung, CF

Pardoll, DM

Wu, TC

机构：

[1] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21287 USA

[2] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[3] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21287 USA

[4] Johns Hopkins Med Inst, Dept Obstet & Gynecol, Baltimore, MD 21287 USA

[5] Johns Hopkins Med Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21287 USA

来源：

VACCINE | 2000年 / 18卷 / 19期

关键词：

HPV-16; DNA vaccine; vaccinia;

D O I：

10.1016/S0264-410X(99)00528-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously linked the sorting signals of the lysosome-associated membrane protein-1 (LAMP-1) to HPV-16 E7 antigen, creating a chimera, Sig/E7/LAMP-1. We found that both Sig/E7/LAMP-1-containing recombinant vaccinia virus (Vac-Sig/E7/LAMP-1) and Sig/E7/LAMP-1 DNA can generate strong antitumor immunity. To determine whether combination of Sig/E7/LAMP-1 DNA and Vac-Sig/E7/LAMP-1 can further enhance immune responses, sequential vaccination with Sig/E7/ LAMP-1 DNA and Vac-Sig/E7/LAMP-1 was given. We found that priming with Sig/E7/LAMP-1 DNA and boosting with Vac-Sig/E7/LAMP-1 generated the strongest E7-specific CD8+ T cell responses. Our results encourage the use of the DNA prime/vaccinia booster regimen in future clinical trials. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2015 / 2022

页数：8

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