Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

被引：56
作者：
Delaporte, RH
Sánchez, GM
Cuellar, AC
Giuliani, A
de Mello, JCP
机构：
[1] Univ Paranaense, Inst Super Ciencias Farmaceut & Bioquim, BR-8750230 Umuarama, Parana, Brazil
[2] Univ Havana, Inst Pharm, Ctr Biol Evaluat & Res, Havana, Cuba
[3] Univ Milan, Dept Med Chem & Biochem, I-20133 Milan, Italy
[4] Univ Estadual Maringa, Dept Farm & Farmacol, BR-87020900 Maringa, Parana, Brazil
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 82卷 / 2-3期
关键词：
Bouchea fluminensis; Verbenaceae; iridoid; lamiide; anti-inflammatory activity; rat-paw edema; lipid peroxidation inhibition;
D O I：
10.1016/S0378-8741(02)00181-2
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Anti-inflammatory activity of an ethanolic extract from Bouchea fluminensis leaves was demonstrated. From de ethanolic extract, the active compound was isolated and characterized as the iridoid lamiide. The activity of lamiide on rat-brain phospholipid peroxidation showed a powerful effect (IC50=0.92+/-0.01 mM) and an anti-inflammatory activity in carrageenin-induced paw edema test (ED50 = 62.3 +/- 7 mg/kg weight). (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：127 / 130
页数：4
相关论文
共 18 条
  • [1] ANTIOXIDANT AND PROOXIDANT PROPERTIES OF ACTIVE ROSEMARY CONSTITUENTS - CARNOSOL AND CARNOSIC ACID
    ARUOMA, OI
    HALLIWELL, B
    AESCHBACH, R
    LOLIGERS, J
    [J]. XENOBIOTICA, 1992, 22 (02) : 257 - 268
  • [2] IRIDOIDS - AN UPDATED REVIEW .2.
    BOROS, CA
    STERMITZ, FR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05): : 1173 - 1246
  • [3] Buege J A, 1978, Methods Enzymol, V52, P302
  • [4] PHLINOSIDE-D AND PHLINOSIDE-E PHENYLPROPANOID GLYCOSIDES, AND IRIDOIDS FROM PHLOMIS-LINEARIS
    CALIS, I
    BASARAN, AA
    SARACOGLU, I
    STICHER, O
    RUEDI, P
    [J]. PHYTOCHEMISTRY, 1991, 30 (09) : 3073 - 3075
  • [5] CARMEN RM, 1994, PLANTA MED, V60, P232
  • [6] Laser photoelectron spectroscopy of H2 and D2:: competing decay channels in 'simple' molecules
    De Lange, CA
    [J]. INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY, 2001, 20 (01) : 1 - 32
  • [7] ICLAL S, 1998, CHEM PHARM BULL, V46, P726
  • [8] 2-DIMENSIONAL NMR-SPECTROSCOPY OF GLYCOSIDES
    KREBS, HC
    HABERMEHL, GG
    [J]. MAGNETIC RESONANCE IN CHEMISTRY, 1992, 30 : S56 - S59
  • [9] Antiinflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis
    Schapoval, EES
    de Vargas, MRW
    Chaves, CG
    Bridi, R
    Zuanazzi, JA
    Henriques, AT
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1998, 60 (01) : 53 - 59
  • [10] Iridoid glucosides from Bouchea fluminensis
    Schuquel, ITA
    Malheiros, A
    Sarragiotto, MH
    Vidotti, GJ
    [J]. PHYTOCHEMISTRY, 1998, 49 (08) : 2409 - 2411
12