Unexpected conserved non-coding DNA blocks in mammals

被引:16
|
作者
Gaffney, DJ [1 ]
Keightley, PD [1 ]
机构
[1] Univ Edinburgh, Sch Biol Sci, Ashworth Labs, Edinburgh EH9 3JT, Midlothian, Scotland
关键词
D O I
10.1016/j.tig.2004.06.011
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The significance of non-coding DNA is a longstanding riddle in the study of molecular evolution. Using a comparative genomics approach, Dermitzakis and colleagues have recently shown that at least some noncoding sequence, frequently ignored as meaningless noise, might bear the signature of natural selection. If functional, it could mark a turning point in the way we think about the evolution of the genome.
引用
收藏
页码:332 / 337
页数:6
相关论文
共 50 条
  • [31] Functional conserved non-coding elements among tunicates and chordates
    Ambrosino, Luca
    Vassalli, Quirino Attilio
    D'Agostino, Ylenia
    Esposito, Riccardo
    Cetrangolo, Viviana
    Caputi, Luigi
    Amoroso, Alessandro
    Aniello, Francesco
    D'Aniello, Salvatore
    Chatzigeorgiou, Marios
    Chiusano, Maria Luisa
    Locascio, Annamaria
    DEVELOPMENTAL BIOLOGY, 2019, 448 (02) : 101 - 110
  • [32] STATISTICAL INFORMATION CHARACTERIZATION OF CONSERVED NON-CODING ELEMENTS IN VERTEBRATES
    Abnizova, I.
    Walter, K.
    te Boekhorst, R.
    Elgar, G.
    Gilks, W. R.
    JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 2007, 5 (2B) : 533 - 547
  • [33] Using cauliflower to find conserved non-coding regions in Arabidopsis
    Colinas, J
    Birnbaum, K
    Benfey, PN
    PLANT PHYSIOLOGY, 2002, 129 (02) : 451 - 454
  • [34] Cis-regulation and conserved non-coding elements in amphioxus
    Beaster-Jones, Laura
    BRIEFINGS IN FUNCTIONAL GENOMICS, 2012, 11 (02) : 118 - 130
  • [35] Escherichia coli non-coding regulatory regions are highly conserved
    Lamoureux, Cameron R.
    Phaneuf, Patrick, V
    Palsson, Bernhard O.
    Zielinski, Daniel C.
    NAR GENOMICS AND BIOINFORMATICS, 2024, 6 (02)
  • [36] In vivo enhancer analysis of human conserved non-coding sequences
    Pennacchio, Len A.
    Ahituv, Nadav
    Moses, Alan M.
    Prabhakar, Shyam
    Nobrega, Marcelo A.
    Shoukry, Malak
    Minovitsky, Simon
    Dubchak, Inna
    Holt, Amy
    Lewis, Keith D.
    Plajzer-Frick, Ingrid
    Akiyama, Jennifer
    De Val, Sarah
    Afzal, Veena
    Black, Brian L.
    Couronne, Olivier
    Eisen, Michael B.
    Visel, Axel
    Rubin, Edward M.
    NATURE, 2006, 444 (7118) : 499 - 502
  • [37] Illuminating functions of evolutionarily conserved long non-coding RNAs
    He, Ruiqiao
    Zhao, Fangqing
    SCIENCE CHINA-LIFE SCIENCES, 2024, 67 (09) : 2043 - 2044
  • [38] Highly conserved non-coding sequences are associated with vertebrate development
    Woolfe, A
    Goodson, M
    Goode, DK
    Snell, P
    McEwen, GK
    Vavouri, T
    Smith, SF
    North, P
    Callaway, H
    Kelly, K
    Walter, K
    Abnizova, I
    Gilks, W
    Edwards, YJK
    Cooke, JE
    Elgar, G
    PLOS BIOLOGY, 2005, 3 (01) : 116 - 130
  • [39] Unexpected Roles of Long Non-Coding RNAs in Cancer Biology
    戚颖
    康亚妮
    赵小东
    JournalofShanghaiJiaotongUniversity(Science), 2014, 19 (05) : 544 - 549
  • [40] Unexpected roles of long non-coding RNAs in cancer biology
    Qi Y.
    Kang Y.-N.
    Zhao X.-D.
    Journal of Shanghai Jiaotong University (Science), 2014, 19 (5) : 544 - 549