Unexpected conserved non-coding DNA blocks in mammals

被引:16
作者
Gaffney, DJ [1 ]
Keightley, PD [1 ]
机构
[1] Univ Edinburgh, Sch Biol Sci, Ashworth Labs, Edinburgh EH9 3JT, Midlothian, Scotland
关键词
D O I
10.1016/j.tig.2004.06.011
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The significance of non-coding DNA is a longstanding riddle in the study of molecular evolution. Using a comparative genomics approach, Dermitzakis and colleagues have recently shown that at least some noncoding sequence, frequently ignored as meaningless noise, might bear the signature of natural selection. If functional, it could mark a turning point in the way we think about the evolution of the genome.
引用
收藏
页码:332 / 337
页数:6
相关论文
共 29 条
  • [1] Ansari-Lari MA, 1998, GENOME RES, V8, P29
  • [2] Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
    Cawley, S
    Bekiranov, S
    Ng, HH
    Kapranov, P
    Sekinger, EA
    Kampa, D
    Piccolboni, A
    Sementchenko, V
    Cheng, J
    Williams, AJ
    Wheeler, R
    Wong, B
    Drenkow, J
    Yamanaka, M
    Patel, S
    Brubaker, S
    Tammana, H
    Helt, G
    Struhl, K
    Gingeras, TR
    [J]. CELL, 2004, 116 (04) : 499 - 509
  • [3] The search for meaning in noncoding DNA
    Clark, AG
    [J]. GENOME RESEARCH, 2001, 11 (08) : 1319 - 1320
  • [4] Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment
    Dermitzakis, ET
    Kirkness, E
    Schwarz, S
    Birney, E
    Reymond, A
    Antonarakis, SE
    [J]. GENOME RESEARCH, 2004, 14 (05) : 852 - 859
  • [5] Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs)
    Dermitzakis, ET
    Reymond, A
    Scamuffa, N
    Ucla, C
    Kirkness, E
    Rossier, C
    Antonarakis, SE
    [J]. SCIENCE, 2003, 302 (5647) : 1033 - 1035
  • [6] Numerous potentially functional but non-genic conserved sequences on human chromosome 21
    Dermitzakis, ET
    Reymond, A
    Lyle, R
    Scamuffa, N
    Ucla, C
    Deutsch, S
    Stevenson, BJ
    Flegel, V
    Bucher, P
    Jongeneel, CV
    Antonarakis, SE
    [J]. NATURE, 2002, 420 (6915) : 578 - 582
  • [7] Active conservation of noncoding sequences revealed by three-way species comparisons
    Dubchak, I
    Brudno, M
    Loots, GG
    Pachter, L
    Mayor, C
    Rubin, EM
    Frazer, KA
    [J]. GENOME RESEARCH, 2000, 10 (09) : 1304 - 1306
  • [8] Multi-species sequence comparison: the next frontier in genome annotation
    Dubchak, I
    Frazer, K
    [J]. GENOME BIOLOGY, 2003, 4 (12)
  • [9] STRONG CONSERVATION OF NONCODING SEQUENCES DURING VERTEBRATES EVOLUTION - POTENTIAL INVOLVEMENT IN POSTTRANSCRIPTIONAL REGULATION OF GENE-EXPRESSION
    DURET, L
    DORKELD, F
    GAUTIER, C
    [J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (10) : 2315 - 2322
  • [10] Distinguishing regulatory DNA from neutral sites
    Elnitski, L
    Hardison, RC
    Li, J
    Yang, S
    Kolbe, D
    Eswara, P
    O'Connor, MJ
    Schwartz, S
    Miller, W
    Chiaromonte, F
    [J]. GENOME RESEARCH, 2003, 13 (01) : 64 - 72