Cells of the Innate and Adaptive Immune Systems in Kaposi's Sarcoma

被引：5

作者：

Ngalamika, Owen ^{[1
]}

Munsaka, Sody ^{[2
]}

机构：

[1] Univ Zambia, Univ Teaching Hosp, Dermatol & Venereol Div, Sch Med, Lusaka, Zambia

[2] Univ Zambia, Sch Hlth Sci, Dept Biomed Sci, Lusaka, Zambia

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2020年 / 2020卷

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; HERPESVIRUS-INFECTION; MEDIATED CYTOTOXICITY; NEUTROPHIL FUNCTION; LANGERHANS CELLS; HIV-INFECTION; MAST-CELLS; IN-VITRO; RESPONSES; AIDS;

D O I：

10.1155/2020/8852221

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Kaposi's sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi's sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.

引用

页数：8

共 100 条

[1] Natural Killer Cells: Development, Maturation, and Clinical Utilization [J].

Abel, Alex M. ;

Yang, Chao ;

Thakar, Monica S. ;

Malarkannan, Subramaniam .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[2] The role of mast cells in allergic inflammation [J].

Amin, Kawa .

RESPIRATORY MEDICINE, 2012, 106 (01) :9-14

[3] Cytotoxic T cells [J].

Andersen, Mads Hald ;

Schrama, David ;

Straten, Per thor ;

Becker, Juergen C. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (01) :32-41

[4] Mast Cell Activation and KSHV Infection in Kaposi Sarcoma [J].

Ayers, Leona W. ;

Barbachano-Guerrero, Arturo ;

McAllister, Shane C. ;

Ritchie, Julie A. ;

Asiago-Reddy, Elizabeth ;

Bartlett, Linda C. ;

Cesarman, Ethel ;

Wang, Dongliang ;

Rochford, Rosemary ;

Martin, Jeffrey N. ;

King, Christine A. .

CLINICAL CANCER RESEARCH, 2018, 24 (20) :5085-5097

[5] The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers - A review and hypothesis [J].

Becker, Y .

VIRUS GENES, 2004, 28 (01) :5-18

[6] Quasi-Complete Response of Classic Kaposi's Sarcoma Treated with Weekly Paclitaxel [J].

Benbrahim, Zineb ;

Arifi, Samia ;

Benhammane, Hafida ;

Inani, Kaoutar ;

Gallouj, Salim ;

Meziane, Meriem ;

Mernissi, Fatima Zahra ;

Mellas, Nawfel ;

El Mesbahi, Andomar .

CASE REPORTS IN ONCOLOGICAL MEDICINE, 2013, 2013

[7] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[8] HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells [J].

Betts, Michael R. ;

Nason, Martha C. ;

West, Sadie M. ;

De Rosa, Stephen C. ;

Migueles, Stephen A. ;

Abraham, Jonathan ;

Lederman, Michael M. ;

Benito, Jose M. ;

Goepfert, Paul A. ;

Connors, Mark ;

Roederer, Mario ;

Koup, Richard A. .

BLOOD, 2006, 107 (12) :4781-4789

[9] Kaposi's sarcoma-associated herpesvirus infection promotes differentiation and polarization of monocytes into tumor-associated macrophages [J].

Bhaskaran, Natarajan ;

Ghosh, Santosh K. ;

Yu, Xiaolan ;

Qin, Sanhai ;

Weinberg, Aaron ;

Pandiyan, Pushpa ;

Ye, Fengchun .

CELL CYCLE, 2017, 16 (17) :1611-1621

[10] Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8 [J].

Blasig, C ;

Zietz, C ;

Haar, B ;

Neipel, F ;

Esser, S ;

Brockmeyer, NH ;

Tschachler, E ;

Colombini, S ;

Ensoli, B ;

Sturzl, M .

JOURNAL OF VIROLOGY, 1997, 71 (10) :7963-7968

← 1 2 3 4 5 6 7 8 9 10 →