Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor

被引：141
作者：
Huffman, JW
Yu, S
Showalter, V
Abood, ME
Wiley, JL
Compton, DR
Martin, BR
Bramblett, RD
Reggio, PH
机构：
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298
[2] KENNESAW STATE UNIV,DEPT CHEM,KENNESAW,GA 30144
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 20期
关键词：
ORIENTATION; BINDING;
D O I：
10.1021/jm960394y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：3875 / 3877
页数：3
相关论文
共 22 条
  • [1] DELTA-9-TETRAHYDROCANNABINOL DISCRIMINATION IN RATS AS A MODEL FOR CANNABIS INTOXICATION
    BALSTER, RL
    PRESCOTT, WR
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1992, 16 (01) : 55 - 62
  • [2] CONSTRUCTION OF A 3D MODEL OF THE CANNABINOID CB1 RECEPTOR - DETERMINATION OF HELIX ENDS AND HELIX ORIENTATION
    BRAMBLETT, RD
    PANU, AM
    BALLESTEROS, JA
    REGGIO, PH
    [J]. LIFE SCIENCES, 1995, 56 (23-24) : 1971 - 1982
  • [3] PALLADIUM-CATALYZED CARBONYLATION OF ENOL TRIFLATES - A NOVEL METHOD FOR ONE-CARBON HOMOLOGATION OF KETONES TO ALPHA,BETA-UNSATURATED CARBOXYLIC-ACID DERIVATIVES
    CACCHI, S
    MORERA, E
    ORTAR, G
    [J]. TETRAHEDRON LETTERS, 1985, 26 (08) : 1109 - 1112
  • [4] PYRIDINE-DERIVED TRIFLATING REAGENTS - AN IMPROVED PREPARATION OF VINYL TRIFLATES FROM METALLO ENOLATES
    COMINS, DL
    DEHGHANI, A
    [J]. TETRAHEDRON LETTERS, 1992, 33 (42) : 6299 - 6302
  • [5] COMPTON DR, 1993, J PHARMACOL EXP THER, V265, P218
  • [6] SYNTHESIS OF 5-(TERT-ALKYL)RESORCINOLS
    DOMINIANNI, SJ
    RYAN, CW
    DEARMITT, CW
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (02) : 344 - 346
  • [7] Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors.
    Gareau, Y
    Dufresne, C
    Gallant, M
    Rochette, C
    Sawyer, N
    Slipetz, DM
    Tremblay, N
    Weech, PK
    Metters, KM
    Labelle, M
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (02) : 189 - 194
  • [8] MOLECULAR-CLONING OF A HUMAN CANNABINOID RECEPTOR WHICH IS ALSO EXPRESSED IN TESTIS
    GERARD, CM
    MOLLEREAU, C
    VASSART, G
    PARMENTIER, M
    [J]. BIOCHEMICAL JOURNAL, 1991, 279 : 129 - 134
  • [9] SYNTHESIS OF (+/-)-11-NOR-9-CARBOXY-DELTA-9-TETRAHYDROCANNABINOL - NEW SYNTHETIC APPROACHES TO CANNABINOIDS
    HUFFMAN, JW
    ZHANG, XH
    WU, MJ
    JOYNER, HH
    PENNINGTON, WT
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (04) : 1481 - 1489
  • [10] SYNTHESIS OF BOTH ENANTIOMERS OF NABILONE FROM A COMMON INTERMEDIATE - ENANTIODIVERGENT SYNTHESIS OF CANNABINOIDS
    HUFFMAN, JW
    JOYNER, HH
    LEE, MD
    JORDAN, RD
    PENNINGTON, WT
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (06) : 2081 - 2086
123