Advances in Single Cell Impedance Cytometry for Biomedical Applications

被引：88

作者：

Petchakup, Chayakorn ^{[1
]}

Li, King Ho Holden ^{[1
]}

Hou, Han Wei ^{[2
]}

机构：

[1] Nanyang Technol Univ, Mech & Aerosp Engn, Singapore 639798, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore

来源：

MICROMACHINES | 2017年 / 8卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

impedance spectroscopy; flow cytometry; single cell analysis; AC FREQUENCY-CHARACTERISTICS; MICRO-COULTER COUNTER; MEMBRANE CAPACITANCE; FLOW CYTOMETER; CYTOPLASM CONDUCTIVITY; DIFFERENTIATION STATE; MICROFLUIDIC SYSTEM; HUMAN BLOOD; SPECTROSCOPY; CLASSIFICATION;

D O I：

10.3390/mi8030087

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Microfluidics impedance cytometry is an emerging research tool for high throughput analysis of dielectric properties of cells and internal cellular components. This label-free method can be used in different biological assays including particle sizing and enumeration, cell phenotyping and disease diagnostics. Herein, we review recent developments in single cell impedance cytometer platforms, their biomedical and clinical applications, and discuss the future directions and challenges in this field.

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