Study on pharmacokinetics of Fe2O3 nanoparticles coated with glutamic acid in mice

被引：0
作者：
Liu Lan [1 ]
Liu Lu [1 ]
Yin Qi-hua [1 ]
Wang Bo [1 ]
Xiong Li-lin [1 ]
Gu Ning [1 ]
Ma Ming [1 ]
Zhang Yu [1 ]
Tang Meng [1 ]
机构：
[1] Jiangsu Dis Prevent & Control Ctr, Nanjing 210009, Peoples R China
来源：
PROCEEDINGS OF THE 3RD INTERNATIONAL ACADEMIC CONFERENCE ON ENVIRONMENTAL AND OCCUPATIONAL MEDICINE | 2006年
关键词：
nanoparticles; isotope tracing technique; pharmacokinetics; concentration-time curve;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The pharmacokinetics of Fe(2)O(3) coated with glutamic acid with mean diameter of 15 nm in mice were determined after intravenous injection using isotope tracing method. This nanoparticles displayed. linear pharmacokinetics. The concentration-time Curve of nano-Fe(2)O(3)-Glu fit mainly two-compartment model. The mean t(1/2)alpha and t(1/2)beta for the 5.12 mg/kg dose group were 0.16 h and 71.65 h, respectively. The distribution test showed that Nano-Fe(2)O(3)-Glu distributed widely in vivo, and the dose in liver and spleen was higher than that in other organs. It could permeate the barriers of blood-brain, blood-eyes and blood-sex gland, whose target tissues may be liver and spleen. Moreover, the time of peak distribution of nano-Fe(2)O(3)-Glu in various tissues was not unanimous.
引用
收藏
页码：179 / 181
页数：3
相关论文
共 50 条
  • [41] Preparation, Surface Modification, and Characteristic of α-Fe2O3 Nanoparticles
    Yuan, Jin-Tao
    Wang, Zhou
    Wang, Lan
    Liu, Rui-Jiang
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2020, 20 (05) : 3031 - 3037
  • [42] Synthesis, characterization and photocatalytic activity of α-Fe2O3 nanoparticles
    Maji, Swarup Kumar
    Mukherjee, Nillohit
    Mondal, Anup
    Adhikary, Bibhutosh
    POLYHEDRON, 2012, 33 (01) : 145 - 149
  • [43] Control Synthesis and Characterization of Monodispersed γ-Fe2O3 Nanoparticles
    Wang Yingsai
    Cui Bin
    Peng Hongxia
    Xia Haiqing
    Chang Zhuguo
    RARE METAL MATERIALS AND ENGINEERING, 2014, 43 (05) : 1187 - 1192
  • [44] γ-Fe2O3 NANOPARTICLES AS A POTENTIAL SENSOR FOR HISTAMINE ISOLATION
    Gagic, Milica
    Kopel, Pavel
    Cernei, Natalia
    Zitka, Ondrej
    Svec, Pavel
    Jamroz, Ewelina
    Adam, Vojtech
    10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R)), 2019, : 365 - 369
  • [45] Characterization of γ-Fe2O3 nanoparticles prepared by transformation of α-FeOOH
    MIAO Hua
    Science Bulletin, 2011, (22) : 2383 - 2388
  • [46] α-Fe2O3 Nanoparticles Synthesized By A Novel Chemical Method
    Patange, M.
    Jadhav, J.
    Biswas, S.
    SOLID STATE PHYSICS, PTS 1 AND 2, 2012, 1447 : 455 - 456
  • [47] Large nonlinear optical properties of Fe2O3 nanoparticles
    Yu, BL
    Zhu, CS
    Gan, FX
    PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES, 2000, 8 (04) : 360 - 364
  • [48] Synthesis of amorphous Fe2O3 nanoparticles by microwave irradiation
    Liao, XH
    Zhu, JJ
    Zhong, W
    Chen, HY
    MATERIALS LETTERS, 2001, 50 (5-6) : 341 - 346
  • [49] Heterostructure Fe2O3–In2O3 Nanoparticles as Hydrogen Gas Sensor
    D. M. Chethana
    T. C. Thanuja
    H. M. Mahesh
    M. S. Kiruba
    H. C. Barshilia
    S. Yallappa
    J. Manjanna
    Journal of Electronic Materials, 2021, 50 : 4313 - 4323
  • [50] Enhancement of properties of vegetable oil with γFe2O3 nanoparticles
    Sharif, S.
    Sadiq, I. O.
    Noordin, M. Y.
    Suhaimi, M. A.
    PROCEEDINGS OF ASIA INTERNATIONAL CONFERENCE ON TRIBOLOGY 2018 (ASIATRIB 2018), 2018, : 432 - 433
12345