Study on pharmacokinetics of Fe2O3 nanoparticles coated with glutamic acid in mice

被引：0
作者：
Liu Lan [1 ]
Liu Lu [1 ]
Yin Qi-hua [1 ]
Wang Bo [1 ]
Xiong Li-lin [1 ]
Gu Ning [1 ]
Ma Ming [1 ]
Zhang Yu [1 ]
Tang Meng [1 ]
机构：
[1] Jiangsu Dis Prevent & Control Ctr, Nanjing 210009, Peoples R China
来源：
PROCEEDINGS OF THE 3RD INTERNATIONAL ACADEMIC CONFERENCE ON ENVIRONMENTAL AND OCCUPATIONAL MEDICINE | 2006年
关键词：
nanoparticles; isotope tracing technique; pharmacokinetics; concentration-time curve;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The pharmacokinetics of Fe(2)O(3) coated with glutamic acid with mean diameter of 15 nm in mice were determined after intravenous injection using isotope tracing method. This nanoparticles displayed. linear pharmacokinetics. The concentration-time Curve of nano-Fe(2)O(3)-Glu fit mainly two-compartment model. The mean t(1/2)alpha and t(1/2)beta for the 5.12 mg/kg dose group were 0.16 h and 71.65 h, respectively. The distribution test showed that Nano-Fe(2)O(3)-Glu distributed widely in vivo, and the dose in liver and spleen was higher than that in other organs. It could permeate the barriers of blood-brain, blood-eyes and blood-sex gland, whose target tissues may be liver and spleen. Moreover, the time of peak distribution of nano-Fe(2)O(3)-Glu in various tissues was not unanimous.
引用
收藏
页码：179 / 181
页数：3
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