The effects of erythropoietin signaling on telomerase regulation in non-erythroid malignant and non-malignant cells

被引：1
作者：
Uziel, Orit [1 ]
Kanfer, Gil [1 ,2 ]
Beery, Einat [1 ]
Yelin, Dana [3 ]
Shepshelovich, Daniel [3 ]
Bakhanashvili, Mary [4 ]
Nordenberg, Jardena [1 ,2 ,5 ]
Lahav, Meir [1 ,3 ]
机构：
[1] Tel Aviv Univ, Sackler Sch Med, Felsenstein Med Res Ctr, Ramat Aviv, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, Ramat Aviv, Israel
[3] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel
[4] Chaim Sheba Med Ctr, Infect Dis Unit, IL-52621 Tel Hashomer, Israel
[5] Beilinson Med Ctr, Endocrinol Lab, IL-49100 Petah Tiqwa, Israel
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 450卷 / 01期
关键词：
Erythropoietin; Telomerase; Telomeres; Lyn-src; RECEPTOR; GROWTH;
D O I：
10.1016/j.bbrc.2014.05.105
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Treatment with erythropoietin (EPO) in several cancers is associated with decreased survival due to cancer progression. Due to the major importance of telomerase in cancer biology we hypothesized that some of these effects may be mediated through EPO effect on telomerase. For this aim we explored the possible effects of EPO on telomerase regulation, cell migration and chemosensitivity in non-erythroid malignant and non-malignant cells. Cell proliferation, telomerase activity (TA) and cell migration increased in response to EPO. EPO had no effect on cancer cells sensitivity to cisplatinum and on the cell cycle status. The inhibition of telomerase modestly repressed the proliferative effect of EPO. Telomere shortening caused by long term inhibition of the enzyme abolished the effect of EPO, suggesting that EPO effects on cancer cells are related to telomere dynamics. TA was correlated with the levels of Epo-R. The increase in TA was mediated post-translationally through the Lyn-Src and not the canonical JAK2 pathway. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：274 / 282
页数：9
相关论文
共 50 条
  • [21] Haploidentical Stem Cell Transplantation After TCR-αβ+ and CD19+ Cells Depletion In Children With Congenital Non-Malignant Disease
    Giardino, Stefano
    Bagnasco, Francesca
    Falco, Michela
    Miano, Maurizio
    Pierri, Filomena
    Risso, Marco
    Terranova, Paola
    Di Martino, Daniela
    Massaccesi, Erika
    Ricci, Margherita
    Chianucci, Benedetta
    Dell'Orso, Gianluca
    Sabatini, Federica
    Podesta, Marina
    Lanino, Edoardo
    Faraci, Maura
    TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (07): : 394.e1 - 394.e9
  • [22] High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
    Nilsson, Maria
    Hagglof, Christina
    Hammarsten, Peter
    Thysell, Elin
    Stattin, Par
    Egevad, Lars
    Granfors, Torvald
    Jernberg, Emma
    Wikstrom, Pernilla
    Bergstrom, Sofia Halin
    Bergh, Anders
    PLOS ONE, 2015, 10 (10):
  • [23] Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells
    Ci, Xinyu
    Li, Bingnan
    Ma, Xueping
    Kong, Feng
    Zheng, Chengyun
    Bjorkholm, Magnus
    Jia, Jihui
    Xu, Dawei
    ONCOTARGET, 2015, 6 (35) : 38079 - 38092
  • [24] Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts
    Dagur, Raghubendra Singh
    Hambarde, Shashank
    Chandna, Sudhir
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 401 (1-2) : 49 - 59
  • [25] ETS-dependent p16INK4a and p21warf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
    von Brandenstein, M.
    Schlosser, M.
    Richter, C.
    Depping, R.
    Fries, J. W. U.
    LIFE SCIENCES, 2012, 91 (13-14) : 562 - 571
  • [26] Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure
    Panagopoulos, Kiriaki
    Cross-Knorr, Sam
    Dillard, Christen
    Pantazatos, Dionysios
    Del Tatto, Michael
    Mills, David
    Goldstein, Lisa
    Renzulli, Joseph
    Quesenberry, Peter
    Chatterjee, Devasis
    MOLECULAR CANCER, 2013, 12
  • [27] Expression of 11β-hydroxysteroid Dehydrogenase Type 1 in Breast Cancer and Adjacent Non-Malignant Tissue. An Immunocytochemical Study
    Lu, Lu
    Zhao, Gang
    Luu-The, Van
    Ouellet, Johanne
    Fan, Zhinmin
    Labrie, Fernand
    Pelletier, Georges
    PATHOLOGY & ONCOLOGY RESEARCH, 2011, 17 (03) : 627 - 632
  • [28] Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells
    Win, H. Y.
    Acevedo-Duncan, M.
    CELL PROLIFERATION, 2009, 42 (02) : 182 - 194
  • [29] Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro
    Stute, Petra
    Reichenbach, Anne
    Szuwart, Thomas
    Kiesel, Ludwig
    Goette, Martin
    MATURITAS, 2012, 71 (04) : 376 - 384
  • [30] Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells
    El Hajj, Joelle
    Nguyen, Eric
    Liu, Qingyuan
    Bouyer, Claire
    Adriaenssens, Eric
    Hilal, George
    Segal-Bendirdjian, Evelyne
    MOLECULAR CANCER, 2018, 17
12345