Genotypic Prediction of Human Immunodeficiency Virus Type 1 CRF02-AG Tropism

被引：43
|
作者：
Raymond, Stephanie [1 ,2 ,3 ]
Delobel, Pierre [2 ,4 ]
Mavigner, Maud [2 ]
Cazabat, Michelle [1 ,2 ]
Souyris, Corinne [1 ,2 ]
Encinas, Stephanie [1 ,2 ]
Sandres-Saune, Karine [1 ,2 ,3 ]
Pasquier, Christophe [1 ,2 ,3 ]
Marchou, Bruno [3 ,4 ]
Massip, Patrice [3 ,4 ]
Izopet, Jacques [1 ,2 ,3 ]
机构：
[1] CHU Toulouse, Hop Purpan, Virol Lab, F-31300 Toulouse, France
[2] INSERM, U563, F-31300 Toulouse, France
[3] Univ Toulouse 3, Fac Med Toulouse Purpan, F-31300 Toulouse, France
[4] CHU Toulouse, Hop Purpan, Serv Malad Infect & Trop, F-31300 Toulouse, France
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 07期
关键词：
CORECEPTOR USAGE; V3; SEQUENCES; PHENOTYPE; MOLECULE; CAMEROON; SUBTYPES; DISEASE; DOMAIN; ENV;
D O I：
10.1128/JCM.02439-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.
引用
收藏
页码：2292 / 2294
页数：3
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