Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation

被引：13
|
作者：
Lai, Maoyi [1 ]
Xiao, Changchun [1 ]
机构：
[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2015年 / 28卷 / 02期
关键词：
microRNAs; miRNA clusters; miR-17-92; B cells; T cells; Lymphoma; MICRORNA CLUSTER; T-CELLS; MIR-17-SIMILAR-TO-92; CLUSTER; EXPRESSION; GENE; MYC; TARGETS; FAMILY; ROLES; AMPLIFICATION;
D O I：
10.1016/j.intimp.2015.03.041
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The miR-17-92 cluster is a prototypical example of a polycistronic miRNA gene. Recently, miR-17-92 has emerged as a pleiotropic regulator in immune system. Its loss or deregulation leads to defects in lymphocyte development and response, and lymphoma development. Although the six individual miRNAs of the cluster are expressed together from the same primary transcript, their relative abundance, functional contributions and interactions vary in different cellular contexts. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：854 / 858
页数：5
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