Drugs for Acute Attack of Pediatric Migraine: A Network Meta-analysis of Randomized Controlled Trials

被引:5
作者
Wang, Guihua [1 ,2 ]
Tan, Tianlin [3 ]
Liu, Yao [3 ]
Hong, Peiwei [1 ,2 ]
机构
[1] Sichuan Univ, Dept Geriatr Med & Neurol, West China Sch Publ Hlth, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China
[3] Xindu Hosp Tradit Chinese Med, Chengdu, Sichuan, Peoples R China
关键词
migraine; pediatric; NSAIDS; triptans; Network meta-analysis; ZOLMITRIPTAN NASAL SPRAY; TENSION-TYPE HEADACHE; DOUBLE-BLIND; COMPARATIVE EFFICACY; ORAL SUMATRIPTAN; SCHOOL-CHILDREN; TOLERABILITY; ADOLESCENTS; RIZATRIPTAN; PREVALENCE;
D O I
10.1016/j.clineuro.2020.105853
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Migraine in pediatric is a common neurological disease, and its prevalence is varying widely. The medication for the acute attack of pediatric migraine is various. we take advantage of network meta-analysis to address the efficacy and rank of these medications. Database including Pubmed and Cochrane Library were queried using a specific searching strategy. The quality of trials enrolled was assessed according to the Cochrane collaboration'tool for assessing risk of bias. The data analysis was conducted by using the core software for Cochrane reviews (Rev Man 5.3) and the Aggregate Data Drug Information System (Addis v1.16.8). The outcomes were pain-free and pain relief at 2 hours post-dose. Totally, twenty trials with high quality including 6029 migraineurs with 6912 attacks randomly assigned to 14 different drugs. The data of ketorolac and prochlorperazine were missing. We found that sumatriptan nasal spray and zolmitriptan nasal spray were superior to placebo in the two efficacy outcomes, whereas almotriptan, rizatriptan, sumatriptan with naproxen sodium, ibuprofen and ibuprofen suspension were superior to placebo only in one of the efficacy outcomes. And in network meta-analysis, we found the best 3 treatments were ibuprofen, sumatriptan with naproxen sodium and ibuprofen suspension in achieving pain-free. Meanwhile, the best 3 treatments were ibuprofen suspension, ibuprofen, and rizatriptan in achieving pain relief. In conclusion, in acute treatments of pediatric migraine, most triptans and NSAIDS were effective to achieve pain-free or pain-relief. And the most effective treatment to achieve pain-free is sumatriptan with naproxen sodium. Ibuprofen and ibuprofen suspension were the most effective treatments to achieve painrelief.
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页数:8
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共 35 条
  • [1] A randomized trial of rizatriptan in migraine attacks in children
    Ahonen, K.
    Hamalainen, M. L.
    Eerola, M.
    Hoppu, K.
    [J]. NEUROLOGY, 2006, 67 (07) : 1135 - 1140
  • [2] Nasal sumatriptan is effective in treatment of migraine attacks in children -: A randomized trial
    Ahonen, K
    Hämäläinen, ML
    Rantala, H
    Hoppu, K
    [J]. NEUROLOGY, 2004, 62 (06) : 883 - 887
  • [3] Ayatollahi S. M. T., 2006, Eastern Mediterranean Health Journal, V12, P809
  • [4] Pharmacotherapy for acute migraines in children and adolescents
    Barbanti, P.
    Grazzi, L.
    Egeo, G.
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2019, 20 (04) : 455 - 463
  • [5] Treatment of pediatric migraine headaches: A randomized, double-blind trial of prochlorperazine versus ketorolac
    Brousseau, DC
    Duffy, SJ
    Anderson, AC
    Linakis, JG
    [J]. ANNALS OF EMERGENCY MEDICINE, 2004, 43 (02) : 256 - 262
  • [6] Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis
    Cipriani, Andrea
    Barbui, Corrado
    Salanti, Georgia
    Rendell, Jennifer
    Brown, Rachel
    Stockton, Sarah
    Purgato, Marianna
    Spineli, Loukia M.
    Goodwin, Guy M.
    Geddes, John R.
    [J]. LANCET, 2011, 378 (9799) : 1306 - 1315
  • [7] Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
    Cipriani, Andrea
    Furukawa, Toshiaki A.
    Salanti, Georgia
    Geddes, John R.
    Higgins, Julian P. T.
    Churchill, Rachel
    Watanabe, Norio
    Nakagawa, Atsuo
    Omori, Ichiro M.
    McGuire, Hugh
    Tansella, Michele
    Barbui, Corrado
    [J]. LANCET, 2009, 373 (9665) : 746 - 758
  • [8] Randomized Trial of Sumatriptan and Naproxen Sodium Combination in Adolescent Migraine
    Derosier, Frederick J.
    Lewis, Donald
    Hershey, Andrew D.
    Winner, Paul K.
    Pearlman, Eric
    Rothner, Arnold David
    Linder, Steven L.
    Goodman, David K.
    Jimenez, Theresa B.
    Granberry, Wendy K.
    Runken, M. Chris
    [J]. PEDIATRICS, 2012, 129 (06) : E1411 - E1420
  • [9] Checking consistency in mixed treatment comparison meta-analysis
    Dias, S.
    Welton, N. J.
    Caldwell, D. M.
    Ades, A. E.
    [J]. STATISTICS IN MEDICINE, 2010, 29 (7-8) : 932 - 944
  • [10] Guidelines of the International Headache Society for controlled trials of acute treatment of migraine attacks in adults: Fourth edition
    Diener, Hans-Christoph
    Tassorelli, Cristina
    Dodick, David W.
    Silberstein, Stephen D.
    Lipton, Richard B.
    Ashina, Messoud
    Becker, Werner J.
    Ferrari, Michel D.
    Goadsby, Peter J.
    Pozo-Rosich, Patricia
    Wang, Shuu-Jiun
    Mandrekar, Jay
    [J]. CEPHALALGIA, 2019, 39 (06) : 687 - 710