The 3-dimensional Simulation of a Novel Degradable Implantable Controlled Drug Delivery

被引:0
作者
Gao, Yang [1 ]
Wang, Xiaopeng [1 ]
Chen, Tianning [1 ]
Chen, Chao [1 ]
机构
[1] Xi An Jiao Tong Univ, Sch Mech Engn, Xian, Peoples R China
来源
ISBE 2011: 2011 INTERNATIONAL CONFERENCE ON BIOMEDICINE AND ENGINEERING, VOL 2 | 2011年
关键词
Controlled drug delivery; Micro-hole; Finie element method; Simulation; 3-dimensional; RELEASE;
D O I
暂无
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In order to eliminate the time lag in the initial drug release, a novel drug delivery microsystem is proposed in this paper. With proper microholes in bonding membrane, the drug release rate can be controlled at a stable level in the whole release process. Based on UV-LIGA technology, this microsystem is fabricated by degradable polymer and suitable for subcutaneous implants. As a significant parameter, the diffusion coefficient of drug in PLGA is estimated by comparing the experimental results of polymer erosion and in-vitro release. The releasing process is simulated in 3-dimensional by the finite element method. The simulation results show that the microholes are beneficial to eliminate the time lag, and the area of microholes has an impact on the release time and the linear drug release rate. Furthermore, the matrix is not only form the drug cavities, but also has some effect on the drug release rate.
引用
收藏
页码:295 / 298
页数:4
相关论文
共 6 条
  • [1] Current micropump technologies and their biomedical applications
    Amirouche, Farid
    Zhou, Yu
    Johnson, Tom
    [J]. MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS, 2009, 15 (05): : 647 - 666
  • [2] Release of mifepristone from biodegradable matrices: experimental and theoretical evaluations
    Charlier, A
    Leclerc, B
    Couarraze, G
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 200 (01) : 115 - 120
  • [3] Modulating drug release and matrix erosion of alginate matrix capsules by micro environmental interaction with calcium ion
    Pongjanyakul, Thaned
    Puttipipatkhachorn, Satit
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 67 (01) : 187 - 195
  • [4] Modeling and simulation of drug delivery from a new type of biodegradable polymer micro-device
    Wang, Xiao-Peng
    Chen, Tian-Ning
    Yang, Zhan-Xiao
    [J]. SENSORS AND ACTUATORS A-PHYSICAL, 2007, 133 (02) : 363 - 367
  • [5] Microfabrication of biodegradable (PLGA) honeycomb-structures and potential applications in implantable drug delivery
    Yang, R
    Chen, TN
    Chen, HL
    Wang, WJ
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2005, 106 (02) : 506 - 511
  • [6] Effect of acidic pH on PLGA microsphere degradation and release
    Zolnik, Banu S.
    Burgess, Diane J.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) : 338 - 344