Engineered polymers for advanced drug delivery

被引：242

作者：

Kim, Sungwon ^{[1
]}

Kim, Jong-Ho ^{[1
]}

Jeon, Oju ^{[1
]}

Kwon, Ick Chan ^{[2
]}

Park, Kinam ^{[1
]}

机构：

[1] Purdue Univ, Dept Pharmaceut & Biomed Engn, W Lafayette, IN 47907 USA

[2] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul, South Korea

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2009年 / 71卷 / 03期

关键词：

Drug delivery; Controlled release; Drug targeting; Smart polymer; Molecular imaging; BLOCK-COPOLYMER MICELLES; SUPERPOROUS HYDROGEL COMPOSITES; RESPONSIVE GENE CARRIER; IN-VIVO; CONTROLLED-RELEASE; INSULIN DELIVERY; QUANTUM DOTS; HEPATOCELLULAR-CARCINOMA; COMBINATORIAL CHEMISTRY; PERSONALIZED MEDICINE;

D O I：

10.1016/j.ejpb.2008.09.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates and drug-containing nano/micro-particles have been used for drug targeting. Engineered polymers and polymeric systems have also been used in new areas, such as molecular imaging as well as in nanotechnology. This review examines the engineered polymers that have been used as traditional drug delivery systems and as more recent applications in nanotechnology. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：420 / 430

页数：11

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