Open-label dose-escalation study of oral 1-octanol in patients with essential tremor

被引：38

作者：

Shill, HA

Bushara, KO

Mari, Z

Reich, M

Hallett, M

机构：

[1] NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA

[2] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA

来源：

NEUROLOGY | 2004年 / 62卷 / 12期

关键词：

D O I：

10.1212/WNL.62.12.2320

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twenty-one single oral doses of 1-octanol were given to patients with essential tremor ( ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.

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页码：2320 / 2322

页数：3

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