Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR Spectroscopy

被引：16

作者：

Meehan-Atrash, Jiries ^{[1
]}

Duell, Anna K. ^{[1
]}

McWhirter, Kevin J. ^{[2
]}

Luo, Wentai ^{[1
,2
]}

Peyton, David H. ^{[1
]}

Strongin, Robert M. ^{[1
]}

机构：

[1] Portland State Univ, Dept Chem, Portland, OR 97207 USA

[2] Portland State Univ, Dept Civil & Environm Engn, Portland, OR 97207 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2019年 / 32卷 / 06期

关键词：

SMOKE PARTICULATE MATTER; TOBACCO; CIGARETTE;

D O I：

10.1021/acs.chemrestox.9b00076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Heat-not-burn products, eg, I quit ordinary smoking (IQOS), are becoming popular alternative tobacco products. The nicotine aerosol protonation state has addiction implications due to differences in absorption kinetics and harshness. Nicotine free-base fraction (alpha(fb)) ranges from 0 to 1. Herein, we report alpha(fb) for IQOS aerosols by exchange-averaged H-1 NMR chemical shifts of the nicotine methyl protons in bulk aerosol and verified by headspace-solid phase micro extraction-gas chromatography-mass spectrometry. The alpha(fb) approximate to 0 for products tested; likely a result of proton transfer from acetic acid and/or other additives in the largely aqueous aerosol. Others reported higher alpha(fb) for these products, however, their methods were subject to error due to solvent perturbation.

引用

页码：974 / 976

页数：3

共 29 条

[1] A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction [J].