Systemic sclerosis: A world wide global analysis

被引：48

作者：

Coral-Alvarado, Paola ^{[1
,2
]}

Pardo, Aryce L. ^{[1
,2
]}

Castano-Rodriguez, Natalia ^{[1
,2
]}

Rojas-Villarraga, Adriana ^{[1
,2
]}

Anaya, Juan-Manuel ^{[1
,2
]}

机构：

[1] Rosario Univ, Sch Med, Ctr Autoimmune Dis Res CREA, Bogota, Colombia

[2] Corp Invest Biol, Medellin, Colombia

来源：

CLINICAL RHEUMATOLOGY | 2009年 / 28卷 / 07期

关键词：

Clinical characteristics; Epidemiology; Systemic sclerosis; PULMONARY ARTERIAL-HYPERTENSION; SERUM ANTINUCLEAR ANTIBODIES; CLINICAL-FEATURES; SEROLOGIC FEATURES; RACIAL-DIFFERENCES; SCLERODERMA; SURVIVAL; DISEASE; PREVALENCE; EPIDEMIOLOGY;

D O I：

10.1007/s10067-009-1144-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to analyze epidemiological tendencies of systemic sclerosis (SSc) around the world in order to identify possible local variations in the presentation and occurrence of the disease. A systematic review of the literature was performed through electronic databases using the keywords "Systemic Sclerosis" and "Clinical Characteristics." Out of a total of 167 articles, 41 were included in the analysis. Significant differences in the mean age at the time of diagnosis, subsets of SSc, clinical characteristics, and presence of antibodies were found between different regions of the word. Because variations in both additive and nonadditive genetic factors and the environmental variance are specific to the investigated population, ethnicity and geography are important characteristics to be considered in the study of SSc and other autoimmune diseases.

引用

页码：757 / 765

页数：9

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