Inhibitors of the human neuraminidase enzymes

被引：33

作者：

Cairo, Christopher W. ^{[1
]}

机构：

[1] Univ Alberta, Alberta Glyc Ctr, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

HUMAN CYTOSOLIC SIALIDASE; PLASMA-MEMBRANE GLYCOPROTEINS; INFLUENZA-VIRUS NEURAMINIDASE; SITE-DIRECTED MUTAGENESIS; COLON-CANCER CELLS; SUBSTRATE RECOGNITION; LYSOSOMAL SIALIDASE; GANGLIOSIDE SIALIDASE; SELECTIVE INHIBITORS; MAMMALIAN SIALIDASES;

D O I：

10.1039/c4md00089g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human neuraminidase enzymes (hNEU) are a family of four isoenzymes that hydrolyze sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play roles in several important signaling pathways and are implicated in diseases such as diabetes and cancer. Despite their importance, only a limited number of studies have sought to identify potent inhibitors for these enzymes. This review summarizes the substrate specificity and known inhibitors of the hNEU isoenzymes, as well as the emerging work on development of isoenzyme-specific inhibitors.

引用

页码：1067 / 1074

页数：8

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