Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

被引：31
作者：
Hao, Wei
Wang, Han
Ye, Qingyu
Zhang, Wen-Xiong
Xi, Zhenfeng [1 ]
机构：
[1] Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem, Beijing 100871, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 22期
关键词：
PROTON-ABSTRACTION MECHANISM; C-H ACTIVATION; EFFICIENT SYNTHESIS; OXIDATIVE ADDITION; DIRECT ARYLATION; DEHYDROGENATIVE CYCLIZATION; INTRAMOLECULAR ARYLATION; HIGHLY FLUORESCENT; ORGANIC-SYNTHESIS; BOND FORMATION;
D O I：
10.1021/acs.orglett.5b02959
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclopentadienephosphine ligand (L1) and palladium were found to be an efficient catalyst system to activate the alpha-C(sp(2))H bond of pyrrole and indole derivatives. Various alkenyl or aryl dibromides could be used to react with pyrrole and indole derivatives to afford multisubstituted indolizines in high yields.
引用
收藏
页码：5674 / 5677
页数：4
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