Novel synthesis of substituted thiophenes by palladium-catalyzed cycloisomerization of (Z)-2-en-4-yne-1-thiols

被引：72
|
作者：
Gabriele, B [1 ]
Salerno, G [1 ]
Fazio, A [1 ]
机构：
[1] Univ Calabria, Dipartimento Chim, I-87030 Cosenza, Italy
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 03期
关键词：
D O I：
10.1021/ol991297c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The first example of palladium-catalyzed cycloisomerization of (Z)-2-en-4-yne-1-thiols 1 to give substituted thiophenes 2 is reported. Cycloisomerization reactions are carried out under nitrogen at 25-100 degrees C in N,N-dimethylacetamide as the solvent in the presence of catalytic amounts of Pdl(2) in conjunction with Kl to give the corresponding thiophenes in 43-94% yield.
引用
收藏
页码：351 / 352
页数：2
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