Novel synthesis of substituted thiophenes by palladium-catalyzed cycloisomerization of (Z)-2-en-4-yne-1-thiols

被引：72

作者：

Gabriele, B ^{[1
]}

Salerno, G ^{[1
]}

Fazio, A ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Chim, I-87030 Cosenza, Italy

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1021/ol991297c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first example of palladium-catalyzed cycloisomerization of (Z)-2-en-4-yne-1-thiols 1 to give substituted thiophenes 2 is reported. Cycloisomerization reactions are carried out under nitrogen at 25-100 degrees C in N,N-dimethylacetamide as the solvent in the presence of catalytic amounts of Pdl(2) in conjunction with Kl to give the corresponding thiophenes in 43-94% yield.

引用

页码：351 / 352

页数：2

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