Role of Interleukin-22 in liver diseases

被引：45

作者：

Pan, Chun-xiao ^{[1
]}

Tang, Jie ^{[1
]}

Wang, Xiao-yu ^{[1
]}

Wu, Fan-rong ^{[1
]}

Ge, Jin-fang ^{[1
]}

Chen, Fei-hu ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China

来源：

INFLAMMATION RESEARCH | 2014年 / 63卷 / 07期

基金：

中国国家自然科学基金;

关键词：

IL-22; Liver disease; Therapeutic; VIRUS-INFECTION; CONCANAVALIN-A; IL-22; INJURY; INFLAMMATION; CELLS; CYTOKINE; INNATE; MICE; HEPATOCYTES;

D O I：

10.1007/s00011-014-0727-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases. IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.

引用

页码：519 / 525

页数：7

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