The role of adipose tissue immune cells in obesity and low-grade inflammation

被引：419

作者：

Mraz, Milos ^{[1
]}

Haluzik, Martin ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Gen Univ Hosp, Dept Med 3,Dept Endocrinol & Metab, Prague 12800 2, Czech Republic

来源：

JOURNAL OF ENDOCRINOLOGY | 2014年 / 222卷 / 03期

关键词：

adipose tissue; immune cells; low-grade inflammation; innate immunity; adaptive immunity; insulin resistance; ALTERNATIVELY ACTIVATED MACROPHAGES; DIET-INDUCED OBESITY; TOLL-LIKE RECEPTOR; KILLER T-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED INSULIN-RESISTANCE; INVARIANT NKT CELLS; NF-KAPPA-B; DENDRITIC CELLS; DIABETES-MELLITUS;

D O I：

10.1530/JOE-14-0283

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.

引用

收藏

页码：R113 / R127

页数：15

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