Novel ABC Transporter Gene, vga(C), Located on a Multiresistance Plasmid from a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain

被引：79
作者：
Kadlec, Kristina [1 ]
Schwarz, Stefan [1 ]
机构：
[1] FLI, Inst Farm Anim Genet, D-31535 Neustadt, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期
关键词：
MONITORING PROGRAM 2004-2006; CONFERRING RESISTANCE; NUCLEOTIDE-SEQUENCE; STREPTOGRAMIN; TETRACYCLINE; SUSCEPTIBILITY; PROTEINS; VARIANT; PIGS;
D O I：
10.1128/AAC.00570-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The vga(C) gene encodes a 523-amino-acid protein which confers resistance not only to streptogramin A antibiotics but also to lincosamides and pleuromutilins. Plasmid pKKS825 also carries the resistance genes aadD, tet(L), and dfrK, which may enable the coselection of vga(C) under selective pressure by kanamycin/neomycin, tetracyclines, and trimethoprim.
引用
收藏
页码：3589 / 3591
页数：3
相关论文
共 22 条
[1]   Comparative analysis of staphylococcal plasmids carrying three streptogramin-resistance genes:: vat-vgb-vga [J].
Allignet, J ;
El Solh, N .
PLASMID, 1999, 42 (02) :134-138
[2]   Characterization of a new staphylococcal gene, vgaB, encoding a putative ABC transporter conferring resistance to streptogramin A and related compounds [J].
Allignet, J ;
El Solh, N .
GENE, 1997, 202 (1-2) :133-138
[3]   Complete Genome Sequence of Macrococcus caseolyticus Strain JS']JSCS5402, Reflecting the Ancestral Genome of the Human-Pathogenic Staphylococci [J].
Baba, Tadashi ;
Kuwahara-Arai, Kyoko ;
Uchiyama, Ikuo ;
Takeuchi, Fumihiko ;
Ito, Teruyo ;
Hiramatsu, Keiichi .
JOURNAL OF BACTERIOLOGY, 2009, 191 (04) :1180-1190
[4]   Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci [J].
Chesneau, O ;
Ligeret, H ;
Hosan-Aghaie, N ;
Morvan, A ;
Dassa, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (03) :973-980
[5]  
CLSI, 2008, APPR STAND
[6]   Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus [J].
Gentry, Daniel R. ;
McCloskey, Lynn ;
Gwynn, Michael N. ;
Rittenhouse, Stephen F. ;
Scangarella, Nicole ;
Shawar, Ribhi ;
Holmes, David J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (12) :4507-4509
[7]   Characterization of a variant of vga(A) conferring resistance to streptogramin A and related compounds [J].
Haroche, J ;
Allignet, J ;
Buchrieser, C ;
El Solh, N .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2271-2275
[8]   Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L) [J].
Kadlec, Kristina ;
Schwarz, Stefan .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (02) :776-778
[9]   Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates [J].
Kehrenberg, C ;
Schwarz, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1156-1163
[10]   Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri [J].
Kehrenberg, C ;
Ojo, KK ;
Schwarz, S .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (05) :936-939
123